Skip to main content
Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules

Fig. 3

Model structures of citrulline residue accommodation in peptide-binding pockets 7 and 9 of HLA-DQ2. a T cell receptor (TCR)-view of the p7Cit anchor and the surrounding pocket 7 residues. The residues of pocket 7 are in van der Waals surface representation (partially transparent) with surfaces colored according to atomic charges (negative, red; neutral, gray; positive, blue). In addition, the HLA-DQ2 residues are shown in stick form (carbon, orange; oxygen, red; nitrogen, blue; hydrogen, white; sulfur, yellow). The p7 citrulline residue is depicted in space-filling form with the same color code as the stick form residues, except for carbon, which is in green. The figure is tilted with respect to the proper TCR view by +25 ° and +10 ° with respect to the x-axis and y-axis respectively. b TCR view of the p9Cit anchor and the surrounding pocket 9 residues. Colors and conventions as in A. Figure is tilted with respect to the proper TCR view by +5 ° and -10 °C with respect to the x-axis and y-axis respectively. c TCR view of the p9Arg anchor and the surrounding pocket 9 residues. Colors and conventions as in A. Figure is tilted as in B

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us