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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis

Fig. 4

p53 modulated the production of proinflammatory factors in FLS. a Expression of IL-6 in FLS was efficiently inhibited following initial transfection of p53 siRNA. After incubation with TNF-α for 24 h, IL-6 greatly increased in the p53-deleted FLS. b, c Inhibition of p53 resulted in more production of IL-6 as well as MMP-1 after 24 h of incubation with IL-1β. d p53 suppressed the production of IL-6 in FLS following the stimulation of IL-1β. Ad adenovirus, IL interleukin, MMP matrix metalloproteinase, sc scrambled RNA control, TNF tumor necrosis factor

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Arthritis Research & Therapy

ISSN: 1478-6362

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