Fig. 6

p53 plays a pivotal role in inhibiting synovial inflammation. The inflammation of the synovium in RA significantly inhibits p53 expression or leads to p53 dysfunction. In turn, suppressed p53 results in increased secretion of IL-6, which further suppresses p53, probably by modulating Th17 differentiation. FLS fibroblast-like synoviocytes, IL interleukin, TNF tumor necrosis factor, TH17 IL-17 producing T helper, Treg regulatory T