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Table 4 Analyses of complement activation markers in the subgroups of patients with systemic sclerosis

From: Analysis of complement biomarkers in systemic sclerosis indicates a distinct pattern in scleroderma renal crisis

  n C4d, mean (SD) p value C3bBbP, mean (SD) p value TCC, mean (SD) p value
Sex    0.96   0.20   0.87
 Male 22 35.6 (40.3)   913 (574)   5.80 (3.69)  
 Female 100 29.2 (18.3)   1119 (661)   8.39 (15.8)  
Subset    0.88   0.11   0.36
 lcSSc 81 30.1 (25.2)   1143 (655)   8.56 (16.4)  
 dcSSc 41 30.8 (20.7)   962 (629)   6.66 (9.34)  
PAH    0.19   0.75   0.76
 No 96 31.8 (25.3)   1069 (645)   7.50 (12.4)  
 Yes 26 25.0 (16.0)   1131 (676)   9.49 (20.5)  
SRC    0.036   <0.001   0.003
 No 104 28.9 (23.7)   1156 (655)   8.57 (15.4)  
 Yes 18 38.6 (22.9)   656 (423)   4.22 (5.54)  
Ab    0.095   0.055   0.016
 ACA 34 30.7 (16.9)   1029 (594)   5.83 (5.70)  
 ATA 22 32.7 (18.8)   1140 (744)   10.8 (22.0)  
 ARA 17 35.0 (22.5)   761 (560)   3.19 (2.59)  
 ANA+ 40 29.5 (32.2)   1195 (642)   10.6 (18.0)  
 ANA 9 18.1 (10.0)   1244 (705)   5.62 (3.36)  
Pitting scar    0.50   0.35   0.76
 No 68 31.0 (26.1)   1071 (658)   9.30 (18.6)  
 Yes 50 28.6 (19.0)   1155 (633)   6.53 (5.62)  
Ulcer    0.35   0.36   0.54
 No 105 30.5 (23.9)   1090 (656)   8.31 (15.3)  
 Yes 14 25.5 (17.8)   1183 (574)   6.19 (6.53)  
Telangiectasias    0.83   0.19   0.39
 No 56 28.5 (17.8)   1003 (586)   6.07 (3.80)  
 Yes 63 31.2 (27.2)   1189 (687)   9.84 (19.6)  
  1. Abbreviations: PAH Pulmonary arterial hypertension, SRC Scleroderma renal crisis, Ab Autoantibodies, ACA Anti-centromere, ATA Anti-topoisomerase I, ARA Anti-RNA polymerase III, ANA + Anti-nuclear but not anti-centromere, anti-topoisomerase I or anti-RNA polymerase III, ANA No anti-nuclear autoantibodies, dcSSc Diffuse cutaneous systemic sclerosis, lcSSc Limited cutaneous systemic sclerosis, TCC Terminal complement complex
  2. Autoantibody analyses were by Kruskal-Wallis test; all others were by Mann-Whitney U test