Table 2 Associations between genetic risk scores and overall RA risk, as well as ACPA-positive and ACPA-negative RA risk

 Linear

2.03 (1.85–2.23)

2.44 (2.19–2.72)

1.21 (1.03–1.44)

 Q1

Reference

Reference

Reference

 Q2 vs Q1

1.40 (1.02–1.93)

1.57 (1.04–2.38)

1.25 (0.77–2.05)

 Q3 vs Q1

2.39 (1.78–3.22)

3.43 (2.36–5.00)

1.33 (0.81–2.16)

 Q4 vs Q1

4.99 (3.77–6.61)

8.01 (5.60–11.45)

1.49 (0.92–2.42)

 Linear

2.13 (1.94–2.34)

2.57 (2.30–2.87)

1.19 (1.00–1.42)

 Q1

Reference

Reference

Reference

 Q2 vs Q1

1.68 (1.21–2.34)

2.70 (1.69–4.33)

1.19 (0.74–1.91)

 Q3 vs Q1

3.64 (2.72–4.88)

8.11 (5.34–12.31)

1.06 (0.65–1.71)

 Q4 vs Q1

7.08 (5.24–9.57)

16.11 (10.51–24.69)

1.47 (0.89–2.41)