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Table 3 Associations between cit-Fib reactivity and serological (anti CCP2 and anti-cit-Fib) and genetic risk markers (HLA-DR SE and PTPN22 risk allele)

From: Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells

  All patients (n = 347) Anti CCP2 (n = 347) Anti-cit-Fib (n = 346)
No Yes P value No Yes P value
Cit-Fib α 35 70 (20.2) 0 (0) 70 (28.0) <0.0001 3 (1.9) 66 (34.74) <0.0001
Cit-Fib α 216,218 44 (12.7) 2 (2.1) 42 (16.8) 0.0001 13 (8.3) 31 (16.32) 0.03
Cit-Fib α 263,271 73 (21.0) 1 (1.0) 72 (28.8) <0.0001 8 (5.1) 64 (33.68) <0.0001
Cit-Fib α 425,426 59 (17.0) 2 (2.1) 57 (22.8) <0.0001 14 (9) 45 (23.68) 0.0003
Reactivity to at least one cit-Fib peptide 168 (48.4) 3 (3.1) 165 (66.0) <0.0001 29 (18.6) 138 (72.63) <0.0001
   HLA-DR SE (n = 326) PTPN22 C1858T (n = 322)
Cit-Fib α 35 70 (20.2) 11 (15.1) 55 (21.74) 0.21 38 (17.4) 28 (27.18) 0.04
Cit-Fib α 216,218 44 (12.7) 12 (16.4) 30 (11.86) 0.30 32 (14.8) 9 (8.74) 0.14
Cit-Fib α 263,271 73 (21.0) 13 (17.8) 57 (22.53) 0.39 39 (17.8) 30 (29.13) 0.02
Cit-Fib α 425,426 59 (17.0) 10 (13.7) 46 (18.18) 0.37 34 (15.5) 23 (22.33) 0.14
Reactivity to at least one cit-Fib peptide 168 (48.4) 34 (46.6) 124 (49.01) 0.71 99 (45.2) 58 (56.31) 0.06
Anti-cit Fib protein 190 (54.9) 29 (40.3) 147 (58.1) 0.01 106 (48.6) 69 (67.0) 0.003
  1. Data represent the numbers (percentage) and p values (uncorrected for multiple comparisons). Cit-Fib citrullinated fibrinogen, CCP cyclic citrullinated peptides, SE shared epitope