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Table 3 Composition of each latent class

From: Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data

 

ERAN

BSRBR TNF inhibitor cohort

BSRBR non-biologic cohort

Concordant/discordant

Con

Con

Con

Dis

Dis

Con

Con

Dis

Dis

Con

Con

Dis

Dis

Descriptor

Mild

Moderate

Severe

Better patient-reported

Worse patient-reported

Moderate

Severe

Better patient-reported

Worse patient-reported

Mild

Moderate

Better patient-reported

Worse patient-reported

Number of subjects

220

329

86

91

102

1544

2117

2289

3955

476

1308

248

549

Percentage of total

26%

38%

10%

11%

12%

16%

21%

23%

40%

18%

51%

10%

21%

ESR

22 (19)

25 (18)

42 (29)

40 (26)

44 (29)

42 (27)

52 (31)

39 (26)

49 (29)

27 (21)

33 (23)

44 (28)

38 (26)

SJC

3 (3)

4 (3)

12 (6)

14 (5)

7 (4)

9 (5)

15 (6)

14 (6)

9 (5)

4 (4)

5 (3)

16 (5)

6 (4)

TJC

2 (3)

5 (4)

22 (4)

11 (5)

9 (5)

9 (4)

23 (4)

21 (4)

11 (4)

4 (4)

7 (5)

20 (6)

11 (6)

VAS

20 (15)

44 (20)

66 (20)

50 (20)

73 (16)

57 (20)

84 (15)

69 (19)

74 (18)

34 (21)

51 (21)

72 (18)

69 (16)

BP

46 (6)

31 (7)

24 (6)

32 (6)

22 (5)

34 (7)

20 (4)

27 (6)

23 (5)

43 (6)

31 (5)

27 (7)

23 (5)

VT

52 (9)

40 (8)

33 (8)

46 (8)

30 (8)

45 (9)

25 (6)

39 (9)

30 (7)

51 (7)

39 (7)

36 (9)

28 (6)

MH

55 (7)

45 (9)

39 (9)

52 (8)

32 (10)

50 (9)

32 (10)

46 (9)

38 (10)

56 (7)

47 (9)

43 (10)

32 (9)

Probability of membership of latent class

  > 80% probability

89%

73%

78%

57%

70%

66%

65%

53%

66%

74%

74%

77%

63%

  > 95% probability

71%

40%

56%

30%

41%

40%

37%

22%

38%

51%

36%

59%

38%

  1. Baseline variables used in latent class analysis are summarised to describe composition of each latent class identified within each cohort. The number of participants and the mean (SD) of each variable are shown. The percentage of cases allocated to each latent class is shown for those with a probability of membership in that class >80% or >95%
  2. Abbreviations: BSRBR British Society for Rheumatology Biologics Registers, Dis Discordant, Con Concordant, ESR Erythrocyte sedimentation rate, SJC Swollen joint count, TJC Tender joint count, VAS Visual analogue scale for general health, BP Short Form Health Survey bodily pain, VT Short Form Health Survey vitality, MH Short Form Health Survey mental health, TNF Tumour necrosis factor