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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats

Fig. 3

Effects of the combination of hyaluronic acid and adelmidrol on mast cell staining in osteoarthritis (OA) knee tissue. Compared with sham knees (a), the MIA + solvent (b) and MIA + 1.0% sodium hyaluronate (c) groups displayed significant increases in the numerical density of toluidine blue-positive cells. In contrast, the combination of HA and adelmidrol at the doses indicated (0.6% adelmidrol + 1.0% sodium hyaluronate (d), and 2% adelmidrol + 1.0% sodium hyaluronate (e)) produced a dose-dependent reduction in mast cell infiltration in the knees of MIA-treated rats. (f) Number of mast cells per unit area of muscle parenchyma (mast cell density). Data are means ± SEM of 10 rats for each group. *P < 0.05 versus sham, °P < 0.05 versus MIA + vehicle

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