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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats

Fig. 4

Effects of HA and adelmidrol combination on plasma levels of matrix metalloproteinases (MMPs). MMPs play a primary role in the downstream signaling pathways in osteoarthritis (OA) and cartilage degradation. The MIA + vehicle and 1% sodium hyaluronate group showed a markedly higher expression of MMP-1 (a), MMP-3 (b), and MMP-9 (c). Compared to the MIA group, the group treated with 0.6% adelmidrol + 1.0% sodium hyaluronate and, in particular, with 2% adelmidrol + 1.0% sodium hyaluronate showed a decrease in MMP-1, MMP-3, and MMP-9 expression (ac, respectively). Data are means ± SEM of 10 rats for each group. *P < 0.05 versus sham, °P < 0.05 versus MIA + vehicle

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