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Table 1 Baseline variables at time of gout diagnosis, ULT start and for ULT stop

From: Factors associated with initiation and persistence of urate-lowering therapy

  At gout diagnosis At ULT start aAt ULT stop
n 7709 2460 1571
Male sex, % 68.4 71.9 71.3
Age, mean 66.5 68.2 68.2
Level of educationb: 9 years or less, % 35.1 37.5 38.2
Level of education: 10–12 years, % 41.8 41.8 42.5
Level of education: more than 12 years, % 19.2 17.2 16.4
Metabolic cardiovascular comorbidity index (MCCI)c, %    
0 53.1 42.5 43.4
1–2 34.9 41.0 39.5
3–4 11.4 15.6 16.0
5–6 0.6 0.9 1.2
>6 0.00 0.00 0.00
Renal diseased, % 12.1 17.8 18.8
”Normal kidney function”e, % 62.9 50.4 53.2
“Reduced kidney function”f, % 31.1 41.9 38.6
Severely reduced kidney function”g, % 5.7 7.5 7.8
End-stage kidney failure”h, % 0.3 0.2 0.4
2011,% 33.4 26.1 13.3
2012, % 33.0 35.8 36.4
2013, % 33.7 38.1 50.4
  1. ULT urate-lowering treatment
  2. aDefined as no ULT dispensation ≥125 days since last dispensation
  3. bMissing data for level of education: 3.8% at gout diagnosis, 3.5% at ULT start and 2.9% at ULT stop
  4. cFor definition (ICD-10 codes) of metabolic cardiovascular comorbidity index see Additional file 2: Table S2
  5. dFor definition (ICD-10 codes) of renal disease see Additional file 1: Table S1
  6. eDefined as eGFR >60 mL/min/1.73 m2
  7. fDefined as eGFR 60–31 mL/min/1.73 m2
  8. gDefined as eGFR 30–10 mL/min/1.73 m2
  9. hDefined as eGFR <10 mL/min/1.73 m2
  10. e-hCreatinine value closest to date of first gout diagnosis within 1 year before until 1 month after, a third (2555) of the incident cases did not have a creatinine value within 1 year before and 1 month after. The vast majority of these, 95%, did not have renal disease. For more details, see Additional file 3: Table S3.