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Table 6 Genes involved in skeletal muscle anabolic, catabolic, and inflammatory pathways

From: Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

Gene ID

Gene name

Rheumatoid arthritis vs. control

Fold change

p value

Ubiquitin-proteasome pathway

 MuRF1

Muscle RING-finger protein-1

−1.02

0.25

 MuRF2

Muscle-specific RING finger-2

−1.01

0.47

 FbxO32

F-box protein 32

1.02

0.88

 FbxO40

F-box protein 40

−1.03

0.37

Autophagy-lysozyme pathway

 Atg5

Autophagy related 5

−1.01

0.77

 Atg7

Autophagy related 7

−1.09

0.13

 NAF1

Nuclear assembly factor 1 ribonucleoprotein

−1.03

0.12

 Lamp2

Lysosomal-associated membrane protein 2

−1.03

0.65

IGF1/Akt signaling pathway

 IGF1

Insulin-like growth factor 1

1.00

0.85

 Akt1

V-Akt murine thymoma viral oncogene homolog 1

1.00

0.92

 Akt2

V-Akt murine thymoma viral oncogene homolog 2

−1.04

0.41

 Rptor

Regulatory associated protein of MTOR, complex 1

1.02

0.45

 Rictor

RPTOR independent companion of MTOR, complex 2

1.01

0.54

 FoxO1

Forkhead box O1

−1.07

0.34

 FoxO3

Forkhead box O3

−1.09

0.39

TGFbeta/Myostatin signaling pathway

 ActRIIIB

ARP3 actin-related protein 3 homolog B

1.02

0.69

 FST

Follistatin

−1.02

0.30

NFkB signaling pathways

 IKBKB

Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta

−1.08

0.17

 IKBKAP

Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase complex-associated protein

1.001

0.43

 TRAF6

TNF receptor-associated factor 6, E3 ubiquitin protein ligase

1.02

0.37

 TRADD

TNFRSF1A-associated via death domain

−1.02

0.46

 Bcl3

B-Cell CLL/lymphoma 3

−1.02

0.32

 TRAF2

TNF receptor-associated factor 2

−1.00

0.95

 TRAF5

TNF receptor-associated factor 5

1.01

0.37

 MAPK8

Mitogen-activated protein kinase 8

−1.01

0.32

 NFkB1

Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B cells 1 (p105/p50)

−1.00

0.97

 NFkB2

Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (p52/p100)

−1.06

0.003