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Table 6 Genes involved in skeletal muscle anabolic, catabolic, and inflammatory pathways

From: Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

Gene ID Gene name Rheumatoid arthritis vs. control
Fold change p value
Ubiquitin-proteasome pathway
 MuRF1 Muscle RING-finger protein-1 −1.02 0.25
 MuRF2 Muscle-specific RING finger-2 −1.01 0.47
 FbxO32 F-box protein 32 1.02 0.88
 FbxO40 F-box protein 40 −1.03 0.37
Autophagy-lysozyme pathway
 Atg5 Autophagy related 5 −1.01 0.77
 Atg7 Autophagy related 7 −1.09 0.13
 NAF1 Nuclear assembly factor 1 ribonucleoprotein −1.03 0.12
 Lamp2 Lysosomal-associated membrane protein 2 −1.03 0.65
IGF1/Akt signaling pathway
 IGF1 Insulin-like growth factor 1 1.00 0.85
 Akt1 V-Akt murine thymoma viral oncogene homolog 1 1.00 0.92
 Akt2 V-Akt murine thymoma viral oncogene homolog 2 −1.04 0.41
 Rptor Regulatory associated protein of MTOR, complex 1 1.02 0.45
 Rictor RPTOR independent companion of MTOR, complex 2 1.01 0.54
 FoxO1 Forkhead box O1 −1.07 0.34
 FoxO3 Forkhead box O3 −1.09 0.39
TGFbeta/Myostatin signaling pathway
 ActRIIIB ARP3 actin-related protein 3 homolog B 1.02 0.69
 FST Follistatin −1.02 0.30
NFkB signaling pathways
 IKBKB Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta −1.08 0.17
 IKBKAP Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase complex-associated protein 1.001 0.43
 TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.02 0.37
 TRADD TNFRSF1A-associated via death domain −1.02 0.46
 Bcl3 B-Cell CLL/lymphoma 3 −1.02 0.32
 TRAF2 TNF receptor-associated factor 2 −1.00 0.95
 TRAF5 TNF receptor-associated factor 5 1.01 0.37
 MAPK8 Mitogen-activated protein kinase 8 −1.01 0.32
 NFkB1 Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B cells 1 (p105/p50) −1.00 0.97
 NFkB2 Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (p52/p100) −1.06 0.003