Table 1 Tertile of sAGEs and baseline characteristics by sex
| Â | Men | Women | P value for sex | ||||||
|---|---|---|---|---|---|---|---|---|---|
Tertile 1 | Tertile 2 | Tertile 3 | Â | Tertile 1 | Tertile 2 | Tertile 3 | Â | ||
18.7–28.0 | 28.1–33.7 | 33.9–69.5 | P value | 17.8–24.8 | 24.9 − 28.9 | 29.0–59.7 | P value | ||
Subjects, n | 56 | 50 | 54 | Â | 104 | 86 | 97 | Â | Â |
Knees, n | 88 | 81 | 86 | Â | 171 | 146 | 161 | Â | Â |
BMI, mean (sd) | 29.0 (3.4) | 29.6 (4.1) | 29.5 (3.8) | 0.65 | 30.1 (5.4) | 29.0 (5.4) | 29.0 (5.5) | 0.26 | 0.98 |
Age, years, mean (sd) | 55.6 (7.7) | 61.7 (8.5) | 66.2 (8.8) | <0.01 | 58.8 (9.3) | 63.1 (8.4) | 64.6 (8.0) | <0.01 | 0.28 |
Ethnicity-Hispanic, n (%) | 1 (1.8) | 2 (4.0) | 1 (1.9) | 0.71 | 0 (0.0) | 2 (2.3) | 1 (1.0) | 0.29 | 0.26 |
Race, n (%) | |||||||||
 White | 54 (96.4) | 49 (98.0) | 48 (88.9) | 0.21 | 100 (96.2) | 85 (98.8) | 91 (93.8) | 0.01 | 0.45 |
 Black | 0 (0.0) | 0 (0.0) | 3 (5.6) | 0 (0.0) | 0 (0.0) | 3 (3.1) | |||
 Other | 2 (3.6) | 1 (2.0) | 3 (5.5) | 4 (3.8) | 1 (1.2) | 3 (3.1) | |||
Past or current smoking, n (%) | 21 (37.5) | 27 (54.0) | 35 (64.8) | 0.02 | 50 (48.1) | 43 (50.0) | 56 (57.7) | 0.36 | 0.99 |
Abdominal circumference, mean (sd) | 102.26 (9.83) | 104.97 (11.28) | 105.18 (10.99) | 0.28 | 108.56 (13.53) | 106.13 (14.02) | 105.79 (12.78) | 0.28 | 0.02 |
WC > sex cut, n (%) | 30 (53.6) | 33 (66.0) | 37 (68.5) | 0.22 | 100 (96.2) | 79 (91.9) | 91 (93.8) | 0.45 | <0. 01 |
Systolic BP, mean (sd) | 122 (14.1) | 125 (15.9) | 128 (13.1) | 0.13 | 122 (14.7) | 123 (14.2) | 124 (17.8) | 0.70 | 0.12 |
Diastolic BP, mean (sd) | 76 (9.1) | 74 (10.4) | 73 (9.5) | 0.20 | 71 (8.1) | 70 (8.7) | 70 (10.6) | 0.41 | <0.01 |
HTN, n (%) | 25 (44.6) | 31 (62.0) | 43 (79.6) | <0.01 | 48 (46.2) | 53 (61.6) | 58 (59.8) | 0.06 | 0.18 |
Dyslipidemia, n (%) | 14 (25.0) | 16 (32.0) | 21 (38.9) | 0.29 | 25 (24.0) | 24 (27.9) | 32 (33.0) | 0.37 | 0.42 |
BMI category, n (%) | |||||||||
 Normal | 3 (8.9) | 7 (14.0) | 6 (11.1) | 0.63 | 23 (22.1) | 23 (26.7) | 25 (25.8) | 0.65 | <0.01 |
 Overweight | 32 (57.1) | 21 (42.0) | 26 (48.2) | 28 (26.9) | 27 (31.4) | 32 (33.0) | |||
 Obese | 19 (33.9) | 22 (44.0) | 22 (40.7) | 53 (61.0) | 36 (41.9) | 40 (41.2) | |||
Knee K/L grade | |||||||||
 0–1 | 49 (55.7) | 35 (43.2) | 40 (46.5) | 0.35 | 73 (42.7) | 51 (34.9) | 67 (41.6) | 0.41 | 0.02 |
 2–3 | 39 (44.3) | 46 (56.8) | 46 (53.5) | 98 (57.3) | 95 (65.1) | 94 (58.4) | |||
Baseline joint space width, mean (se) | 6.069 (0.164) | 6.247 (0.170) | 6.403 (0.166) | 0.36 | 5.159 (0.114) | 5.298 (0.116) | 5.329 (0.108) | 0.52 | <0.01 |
Baseline joint space narrowing (n, %) | |||||||||
 OARSI 0 | 50 (56.8) | 34 (42.0) | 35 (40.7) | 0.06 | 99 (57.9) | 71 (48.6) | 76 (47.2) | 0.24 | 0.90 |
 OARSI 1 | 23 (26.1) | 27 (33.3) | 28 (32.6) | 38 (22.2) | 44 (30.1) | 48 (29.8) | |||
 OARSI 2 | 15 (17.1) | 20 (24.7) | 23 (26.7) | 34 (19.9) | 31 (21.2) | 37 (23.0) | |||