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Fig. 8 | Arthritis Research & Therapy

Fig. 8

From: Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes

Fig. 8

Monocyte subsets and Siglec1 expression in dcSSc patients and HD. a Representative monocyte subsets from PBMCs of diffuse cutaneous systemic sclerosis (dcSSc) patients and healthy donors (HDs) defined by the expression of CD14 and CD16 and gating by FACS analysis as CD14+/CD16– (classical, 68% HD), CD14+/CD16+ (intermediate, 2.3% HD), and CD14–/CD16+ (non-classical, 10.4 HD). b Number of monocytes (%) in HD compared to dcSSc patients. c Frequencies of classical, intermediate, and non-classic monocyte subsets in HD and dcSSc patients. d Expression of Siglec1 in the indicated subsets. P values calculated using two-tailed t test. Arrows and circles indicate the representative sample for each class of monocytes shown in panel a

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