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Table 1 Clinical and demographic characteristics of the subjects enrolled in the study

From: Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes

  dcSSc* HD
Number of subjects, n 53 34
Age in years, mean ± SE (range) 44 ± 1.8
(23–71)
41 ± 2.7
(23–65)
Female, % 96 94
mRSS**, mean ± SE 17 ± 0.7
Monocytes infected with recombinant EBV (qPCR, Western blot and immunofluorescence staining experiments), n 14 8
Monocytes freshly isolated (RT-PCR for DNA, qPCR, Western blot and immunostaining experiments), n 8 6
PBMCs (FACS analysis experiments), n 13 12
Skin biopsies (immunostaining experiments), n 18 8
  1. *Inclusion criteria: disease duration <5 years; patients naïve for immunosuppressive therapy (IT) or >6 months free of IT
  2. dcSSc diffuse cutaneous systemic sclerosis, EBV Epstein-Barr virus, HD healthy donor, mRSS modified Rodnan Skin Score, PBMC peripheral blood mononuclear cell, qPCR quantitative polymerase chain reaction, RT-PCR real-time polymerase chain reaction, SE standard error