Variable | Number of events (n = 12,522) | Crude HR | (95% CI) | p Value | Adjusted HR | (95% CI) | p Value |
---|---|---|---|---|---|---|---|
Received acupuncture | |||||||
 No | 8133 | 1.00 | Reference |  | 1.00 | Reference |  |
 Yes | 4389 | 0.48 | (0.46–0.5) | <0.0001 | 0.43 | (0.41–0.45) | <0.0001 |
Sex | |||||||
 Female | 7138 | 1.00 | Reference |  | 1.00 | Reference |  |
 Male | 5384 | 0.98 | (0.95–1.02) | 0.3907 | 1.03 | (0.99–1.07) | 0.1072 |
Age group, years | |||||||
 18–39 | 1248 | 1.00 | Reference |  | 1.00 | Reference |  |
 40–59 | 7946 | 5.24 | (4.94–5.56) | <0.0001 | 4.24 | (3.99–4.51) | <0.0001 |
 ≥60 | 3328 | 11.33 | (10.62–12.1) | <0.0001 | 6.24 | (5.81–6.71) | <0.0001 |
Baseline comorbidities (reference = nonsite comorbidity) | |||||||
 Diabetes mellitus | 2994 | 2.9 | (2.78–3.02) | <0.0001 | 1.37 | (1.31–1.44) | <0.0001 |
 Hypertension | 6188 | 4.03 | (3.89–4.18) | <0.0001 | 2.20 | (2.11–2.3) | <0.0001 |
 Hyperlipidemia | 4452 | 2.88 | (2.78–2.99) | <0.0001 | 1.63 | (1.56–1.7) | <0.0001 |
 Congestive heart failure | 298 | 3.19 | (2.85–3.58) | <0.0001 | 1.17 | (1.04–1.32) | 0.0078 |
 Cerebrovascular diseases | 1966 | 2.81 | (2.68–2.95) | <0.0001 | 1.25 | (1.19–1.32) | <0.0001 |
 Depression | 803 | 1.48 | (1.38–1.59) | <0.0001 | 1.1 | (1.02–1.18) | 0.0131 |
 Anxiety | 1960 | 1.61 | (1.53–1.69) | <0.0001 | 1.21 | (1.15–1.27) | <0.0001 |
 Alcoholism or alcohol-related disorders | 57 | 0.97 | (0.75–1.25) | 0.8031 | 0.93 | (0.72–1.21) | 0.5941 |
 Tobacco dependence | 39 | 0.9 | (0.66–1.23) | 0.5098 | 0.83 | (0.6–1.13) | 0.2391 |
 Obesity | 109 | 1.34 | (1.11–1.62) | 0.0024 | 1 | (0.83–1.21) | 0.9629 |
Drugs used | |||||||
 Oral steroids | 7490 | 0.62 | (0.6–0.64) | <0.0001 | 0.54 | (0.52–0.56) | <0.0001 |
 NSAIDs | 11,804 | 0.21 | (0.19–0.23) | <0.0001 | 0.24 | (0.22–0.26) | <0.0001 |
 Statins | 2218 | 1.28 | (1.22–1.34) | <0.0001 | 0.55 | (0.52–0.58) | <0.0001 |