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Table 2 Hazard ratios of coronary heart disease associated with acupuncture and covariates among patients with fibromyalgia

From: Acupuncture decreased the risk of coronary heart disease in patients with fibromyalgia in Taiwan: a nationwide matched cohort study

Variable

Number of events (n = 12,522)

Crude HR

(95% CI)

p Value

Adjusted HR

(95% CI)

p Value

Received acupuncture

 No

8133

1.00

Reference

 

1.00

Reference

 

 Yes

4389

0.48

(0.46–0.5)

<0.0001

0.43

(0.41–0.45)

<0.0001

Sex

 Female

7138

1.00

Reference

 

1.00

Reference

 

 Male

5384

0.98

(0.95–1.02)

0.3907

1.03

(0.99–1.07)

0.1072

Age group, years

 18–39

1248

1.00

Reference

 

1.00

Reference

 

 40–59

7946

5.24

(4.94–5.56)

<0.0001

4.24

(3.99–4.51)

<0.0001

 ≥60

3328

11.33

(10.62–12.1)

<0.0001

6.24

(5.81–6.71)

<0.0001

Baseline comorbidities (reference = nonsite comorbidity)

 Diabetes mellitus

2994

2.9

(2.78–3.02)

<0.0001

1.37

(1.31–1.44)

<0.0001

 Hypertension

6188

4.03

(3.89–4.18)

<0.0001

2.20

(2.11–2.3)

<0.0001

 Hyperlipidemia

4452

2.88

(2.78–2.99)

<0.0001

1.63

(1.56–1.7)

<0.0001

 Congestive heart failure

298

3.19

(2.85–3.58)

<0.0001

1.17

(1.04–1.32)

0.0078

 Cerebrovascular diseases

1966

2.81

(2.68–2.95)

<0.0001

1.25

(1.19–1.32)

<0.0001

 Depression

803

1.48

(1.38–1.59)

<0.0001

1.1

(1.02–1.18)

0.0131

 Anxiety

1960

1.61

(1.53–1.69)

<0.0001

1.21

(1.15–1.27)

<0.0001

 Alcoholism or alcohol-related disorders

57

0.97

(0.75–1.25)

0.8031

0.93

(0.72–1.21)

0.5941

 Tobacco dependence

39

0.9

(0.66–1.23)

0.5098

0.83

(0.6–1.13)

0.2391

 Obesity

109

1.34

(1.11–1.62)

0.0024

1

(0.83–1.21)

0.9629

Drugs used

 Oral steroids

7490

0.62

(0.6–0.64)

<0.0001

0.54

(0.52–0.56)

<0.0001

 NSAIDs

11,804

0.21

(0.19–0.23)

<0.0001

0.24

(0.22–0.26)

<0.0001

 Statins

2218

1.28

(1.22–1.34)

<0.0001

0.55

(0.52–0.58)

<0.0001

  1. NSAIDs Nonsteroidal anti-inflammatory drugs
  2. a Crude HR represents relative hazard ratio
  3. b Adjusted HR represents adjusted hazard ratio mutually adjusted for accepted acupuncture, age, sex, diabetes mellitus, hypertension, hyperlipidemia, congestive heart failure, cerebrovascular diseases, depression, anxiety, alcoholism or alcohol-related disorders, tobacco dependence, obesity, oral steroids, NSAIDs, and statins in Cox proportional hazards regression