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Table 1 Study participant characteristics

From: Presence of an interferon signature in individuals who are anti-nuclear antibody positive lacking a systemic autoimmune rheumatic disease diagnosis

  Healthy control subjects (n = 20) ANA+ no symptoms (n = 38) UCTD (n = 28) SARD (n = 58) SSc (n = 26) SLE (n = 6) SS (n = 23) DM/MCTD (n = 3)
Female sex, n (%) 18 (90) 37 (97.4) 27 (96.4) 54 (93.1) 24 (92.3) 6 (100) 21 (91.3) 3 (100)
Age, years, mean ± SD 41 ± 12.4 44.1 ± 14.3 47.5 ± 15.4 51.5 ± 14.4 52.8 ± 14.7 39 ± 12.3 54.8 ± 12.7 39.3 ± 6.6
Anti-malarials, n (%) 0 (0) 5 (13.2) 4 (14.3) 7 (12.1) 2 (7.7) 2 (33.3) 2 (8.7) 1 (33.3)
Ethnicity, n (%)
 Caucasian 9 (45) 23 (60.5) 20 (71.4) 41 (70.7) 18 (69.2) 4 (66.7) 17 (73.9) 2 (66.7)
 African 1 (5) 4 (10.5) 3 (10.7) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
 Asian 1 (5) 1 (2.6) 3 (10.7) 3 (5.2) 1 (3.8) 0 (0) 2 (8.7) 0 (0)
 Southeast Asian 3 (15) 5 (13.2) 0 (0) 7 (12.1) 3 (11.5) 2 (33.3) 2 (8.7) 0 (0)
 Filipino 4 (20) 1 (2.6) 1 (3.6) 4 (6.9) 3 (11.5) 0 (0) 0 (0) 1 (33.3)
 Hispanic 1 (5) 1 (2.6) 1 (3.6) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
 Other 1 (5) 3 (7.9) 0 (0) 3 (5.2) 1 (3.8) 0 (0) 2 (8.7) 0 (0)
Specific antibodies, n (%)
 dsDNA 0 (0) 2 (5.3) 4 (14.3) 9 (15.5) 3 (11.5) 2 (33.3) 3 (13.0) 1 (33.3)
 Ro 0 (0) 7 (18.4) 8 (28.6) 30 (51.7) 4 (15.4) 3 (50) 23 (100) 0 (0)
 La 0 (0) 2 (5.3) 4a (14.3) 18 (31.0) 0 (0) 1 (16.7) 17 (73.9) 0 (0)
 Sm 0 (0) 0 (0) 2 (7.1) 3 (5.2) 0 (0) 2 (33.3) 0 (0) 1 (33.3)
 Sm/RNP 0 (0) 0 (0) 5 (17.9) 6 (10.3) 2 (7.7) 2 (33.3) 0 (0) 2 (66.7)
 RNP 0 (0) 4 (10.5) 4 (14.3) 8 (13.8) 2 (7.7) 3 (50) 1 (4.3) 2 (66.7)
 Scl-70 0 (0) 0 (0) 2 (7.1) 10 (17.2) 7 (26.9) 1 (16.7) 2 (8.7) 0 (0)
 Jo-1 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
 Centromere 0 (0) 1 (2.6) 1 (3.6) 17 (29.3) 14 (53.8) 1 (16.7) 1 (4.3) 1 (33.3)
 Chromatin 0 (0) 2 (5.3) 4 (14.3) 6 (10.3) 1 (3.8) 3 (50) 0 (0) 2 (66.7)
  1. Abbreviations: ANA Anti-nuclear antibody, UCTD Undifferentiated connective tissue disease, SARD Systemic autoimmune rheumatic disease, SSc Systemic sclerosis, SS Sjögren’s syndrome, SLE Systemic lupus erythematosus, DM Dermatomyositis, MCTD Mixed connective tissue disease, dsDNA Double-stranded DNA, Sm Smith, RNP Ribonuclear protein
  2. aAll patients that were anti-La antibody positive were anti-Ro antibody positive, except for 1 patient with UCTD