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Table 2 Characteristics of patients with SSc by disease subset

From: Epidemiology and disease characteristics of systemic sclerosis-related pulmonary arterial hypertension: results from a real-life screening programme

  Limited Diffuse P value
n = 1122 n = 377
mean ± SD or % mean ± SD or %
Age at recruitment, years 58.8 ± 12.2 53.1 ± 13.1 <0.001
Female 89.5% 74.9% <0.001
Disease durationa (non-Raynaud) at recruitment, years 12.2 ± 10.8 8.1 ± 8.7 <0.001
Anti-centromere pattern ANA 59.2% 9.6% <0.001
Scl 70 positive 8.9% 31.1% <0.001
RNA polymerase III positive 5.4% 39.6% <0.001
ILD (HRCT scan) 236 (21.11%) 154 (40.9%) <0.001
PAH (RHC) 142 (12.7%) 38 (10.1%) 0.40
Rodnan skin score (highest ever) 7.7 ± 5.4 22.7 ± 9.9 <0.001
Digital ulcers ever 39.6% 60.8% <0.001
Joint contractures ever 28.5% 71.2% <0.001
Renal crisis ever 0.9% 7.7% <0.001
Gastro-oesophageal reflux 80.3% 82.7% 0.29
Anal incontinence 27.9% 25.6% 0.39
  1. ANA antinuclear antibodies, ILD interstitial lung disease, HRCT high-resolution chest computed tomography, PAH pulmonary arterial hypertension, RHC right-heart catheterisation
  2. aDisease duration defined as from first non-Raynaud’s disease manifestation. Disease manifestations are defined as present if ever present from time of diagnosis of systemic sclerosis (SSc)