Table 2 SLC2A9 and ABCG2 genotype frequency in the entire group and in ancestral groups according to tophus status
From: Population-specific association between ABCG2 variants and tophaceous disease in people with gout
All participants | Non-Polynesian ancestry | Māori or Pacific ancestry | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
With data, % | No tophi (n = 1151) | Tophi (n = 627) | P a | With data, % | No tophi (n = 639) | Tophi (n = 288) | P a | With data, % | No tophi (n = 512) | Tophi (n = 339) | P a | |
SLC2A9 rs11942223 protective allele (C) present, n (%) | 100 | 204 (17.7%) | 94 (15.0%) | 0.14 | 100 | 168 (26.3%) | 69 (24.0%) | 0.45 | 100 | 36 (7.0%) | 25 (7.4%) | 0.85 |
ABCG2 rs2231142 risk allele (T) present, n (%) | 100 | 483 (42.0%) | 296 (47.2%) | 0.033 | 100 | 263 (41.2%) | 116 (40.3%) | 0.80 | 100 | 220 (43.0%) | 180 (53.1%) | 0.004 |
ABCG2 rs10011796 risk allele (T) present, n (%) | 97.9 | 917 (81.7%) | 529 (85.6%) | 0.039 | 97.5 | 490 (78.9%) | 230 (81.3%) | 0.41 | 98.2 | 427 (85.2%) | 299 (89.3%) | 0.092 |