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Table 5 ABCG2 analysis in Māori or Pacific participants who had at least three Polynesian grandparents, according to tophus status

From: Population-specific association between ABCG2 variants and tophaceous disease in people with gout

ABCG2 variant Risk allele   Māori or Pacific ancestry (n = 689) Eastern Polynesian ancestry (n = 323) Western Polynesian ancestry (n = 366)
Allelic OR (95% CI) P Allelic OR (95% CI) P Allelic OR (95% CI) P
rs2231142 T Unadjusted 1.77 (1.30–2.42) <0.001 1.65 (0.98–2.78) 0.059 1.77 (1.10–2.87) 0.020
   Adjusted for age and sex 1.76 (1.28–2.42) <0.001 1.60 (0.95–2.69) 0.077 1.86 (1.14–3.04) 0.013
   Adjusted for age, sex, highest recorded urate, serum creatinine and disease duration 1.63 (1.17–2.28) 0.004 1.29 (0.74–2.26) 0.37 1.70 (1.01–2.86) 0.045
rs10011796 T Unadjusted 1.73 (1.04–2.88) 0.036 0.90 (0.47–1.69) 0.73 4.61 (1.73–12.26) 0.002
   Adjusted for age and sex 1.74 (1.04–2.91) 0.034 0.91 (0.48–1.73) 0.78 4.58 (1.72–12.22) 0.002
   Adjusted for age, sex, highest recorded urate, serum creatinine and disease duration 1.72 (1.002–2.95) 0.049 0.89 (0.45–1.77) 0.75 3.90 (1.42–10.68) 0.008