Table 1 Baseline clinical, virologic and laboratory parameters of 22 patients with chronic hepatitis C virus infection with mixed cryoglobulinaemia
Parameters | Data |
|---|---|
Age, years, mean ± SD (range) | 66.9 ± 11.2 (46–84) |
Female sex, n (%) | 14 (63.6) |
Serum HCV RNA, logarithmic IU/ml, mean ± SD | 6.02 ± 1.2 (2.1–7.7) |
HCV genotype, n (%) | |
GT1 | 14 (63.6) |
GT2 | 7 (31.8) |
GT3 | 1 (4.6) |
Cryocrit, %, mean ± SD (range) | 1.8 ± 1.3 (0.5–4) |
Cryoglobulin type, n (%) | |
II | 21 (95.4) |
III | 1 (4.6) |
C3, mg/dl (n.v. 90–180) (mean ± SD) | 93.4 ± 15.3 (51–118) |
C4, mg/dl (n.v. 10–40) (mean ± SD) | 9.6 ± 7.3 (0–24) |
RF, IU/ml (n.v. 10–15) (mean ± SD) | 69.3 ± 119.1 (0–530) |
Clinical features, n (%) | |
Meltzer’s triad | 22 (100) |
Glomerulonephritis | 4 (18.1) |
Peripheral neuropathy | 2 (9.1) |
Liver involvement | |
ALT, IU/L (n.v. 12–78) (mean ± SD) | 104.8 ± 144.7 (13–668) |
Cirrhosis, n (%) | 12 (54.5) |
HCV-related tumours, n (%) | |
Hepatocellular carcinoma | 2 (10) |
Non-Hodgkin lymphoma | 1 (5) |
Small lymphocytic lymphoma | 1 (5) |