Structural predictors of response to intra-articular steroid injection in symptomatic knee osteoarthritis

Maricar, Nasimah; Parkes, Matthew J.; Callaghan, Michael J.; Hutchinson, Charles E.; Gait, Andrew D.; Hodgson, Richard; Felson, David T.; O’Neill, Terence W.

doi:10.1186/s13075-017-1292-2

Arthritis Research & Therapy

Table 3 Baseline imaging characteristics and their relation to change in pain at 2 weeks among persons treated with intra-articular steroids

From: Structural predictors of response to intra-articular steroid injection in symptomatic knee osteoarthritis

Predictor variable in regression	KOOS pain score			Pain on nominated activity VAS
Predictor variable in regression	N	b coefficient (95% CI)^c	P value	N	b coefficient (95% CI)^d	P value
MRI (WORMS)
Synovitis maximal score (0–3)	109	-1.94 (-11.15 to 7.26)	0.677	96	0.45 (-0.83 to 1.74)	0.487
Bone marrow lesion maximal score (0–3)	109	-3.48 (-7.76 to 0.80)	0.110	96	0.76 (0.16 to 1.36)*	0.013
Bone attrition maximal score (0–3)	109	-1.78 (-6.98 to 3.42)	0.498	96	-0.07 (-0.81 to 0.66)	0.846
Cartilage damage maximal score (0–6)	109	0.09 (-2.55 to 2.72)	0.948	96	0.16 (-0.20 to 0.53)	0.378
Cyst maximal score (0–3)	108	0.56 (-4.48 to 5.60)	0.827	95	0.27 (-0.48 to 1.01)	0.475
Menisci damage maximal score (0–6)	109	-2.12 (-4.49 to 0.25)	0.079	96	0.37 (0.04 to 0.70)*	0.027
Osteophyte maximal score (0–7)	109	0.56 (-2.23 to 3.36)	0.690	96	0.18 (-0.22 to 0.57)	0.377
Synovial effusion (0–3)	109	-1.22 (-5.90, 3.46)	0.608	96	0.17 (-0.49 to 0.83)	0.606
MRI (quantitative)
Synovial tissue volume (1000 mm³)	111	-0.05 (-0.67 to 0.57)	0.883	98	0.03 (-0.05 to 0.12)	0.408
Radiographs
Tibiofemoral KL score (0–4)	186	-2.40 (-6.80 to 2.00)	0.284	170	0.66 (0.02 to 1.30)*	0.042
Patellofemoral KL score (0–4)	187	-0.001 (-3.16 to 3.16)	0.999	171	0.64 (0.18 to 1.10)*	0.006
Overall KL maximal score^a (0–4)	187	-1.97 (-6.64 to 2.71)	0.408	171	0.94 (0.27 to 1.62)*	0.007
Lateral tibiofemoral JSN score (0–3)	185	-0.001 (-4.12 to 4.12)	1.000	169	0.05 (-0.56 to 0.67)	0.865
Medial tibiofemoral JSN score (0–3)	186	-1.26 (-5.17 to 2.65)	0.524	170	0.21 (-0.38 to 0.79)	0.486
Patellofemoral JSN score (0–3)	178	-0.52 (-3.60 to 2.56)	0.738	162	0.52 (0.06 to 0.98)*	0.026
Overall JSN maximal score^b (0–3)	186	-1.34 (-5.26 to 2.57)	0.499	170	0.72 (0.14 to 1.29)*	0.015
Knee mal-alignment angle (per degree)	191	0.03 (-0.53 to 0.59)	0.924	173	-0.04 (-0.13 to 0.04)	0.291

KOOS Knee Injury and Osteoarthritis Outcome Score, VAS visual analogue scale, MRI magnetic resonance imaging, WORMS Whole Organ Magnetic Resonance Imaging Score, KL Kellgren-Lawrence, JSN joint space narrowing. Results shown are from fixed panel regression. ^amaximal KL grade of the tibiofemoral or patellofemoral joint; ^bmaximal JSN score of the lateral or medial tibiofemoral or patellofemoral joint; ^cKOOS pain score ranges from 0–100 with lower scores representing more severe pain. Negative coefficients signify that more severe imaging findings were associated with less pain improvement; ^dpain on nominated activity ranged from 0 to 10 with higher values representing more severe pain. Positive coefficients signify that more severe imaging findings were associated with less pain improvement. *Represent results that are significant at p < 0.05

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