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Table 3 Baseline imaging characteristics and their relation to change in pain at 2 weeks among persons treated with intra-articular steroids

From: Structural predictors of response to intra-articular steroid injection in symptomatic knee osteoarthritis

Predictor variable in regression KOOS pain score Pain on nominated activity VAS
N b coefficient (95% CI)c P value N b coefficient (95% CI)d P value
MRI (WORMS)
 Synovitis maximal score (0–3) 109 -1.94 (-11.15 to 7.26) 0.677 96 0.45 (-0.83 to 1.74) 0.487
 Bone marrow lesion maximal score (0–3) 109 -3.48 (-7.76 to 0.80) 0.110 96 0.76 (0.16 to 1.36)* 0.013
 Bone attrition maximal score (0–3) 109 -1.78 (-6.98 to 3.42) 0.498 96 -0.07 (-0.81 to 0.66) 0.846
 Cartilage damage maximal score (0–6) 109 0.09 (-2.55 to 2.72) 0.948 96 0.16 (-0.20 to 0.53) 0.378
 Cyst maximal score (0–3) 108 0.56 (-4.48 to 5.60) 0.827 95 0.27 (-0.48 to 1.01) 0.475
 Menisci damage maximal score (0–6) 109 -2.12 (-4.49 to 0.25) 0.079 96 0.37 (0.04 to 0.70)* 0.027
 Osteophyte maximal score (0–7) 109 0.56 (-2.23 to 3.36) 0.690 96 0.18 (-0.22 to 0.57) 0.377
 Synovial effusion (0–3) 109 -1.22 (-5.90, 3.46) 0.608 96 0.17 (-0.49 to 0.83) 0.606
MRI (quantitative)
 Synovial tissue volume (1000 mm3) 111 -0.05 (-0.67 to 0.57) 0.883 98 0.03 (-0.05 to 0.12) 0.408
Radiographs
 Tibiofemoral KL score (0–4) 186 -2.40 (-6.80 to 2.00) 0.284 170 0.66 (0.02 to 1.30)* 0.042
 Patellofemoral KL score (0–4) 187 -0.001 (-3.16 to 3.16) 0.999 171 0.64 (0.18 to 1.10)* 0.006
 Overall KL maximal scorea (0–4) 187 -1.97 (-6.64 to 2.71) 0.408 171 0.94 (0.27 to 1.62)* 0.007
 Lateral tibiofemoral JSN score (0–3) 185 -0.001 (-4.12 to 4.12) 1.000 169 0.05 (-0.56 to 0.67) 0.865
 Medial tibiofemoral JSN score (0–3) 186 -1.26 (-5.17 to 2.65) 0.524 170 0.21 (-0.38 to 0.79) 0.486
 Patellofemoral JSN score (0–3) 178 -0.52 (-3.60 to 2.56) 0.738 162 0.52 (0.06 to 0.98)* 0.026
 Overall JSN maximal scoreb (0–3) 186 -1.34 (-5.26 to 2.57) 0.499 170 0.72 (0.14 to 1.29)* 0.015
 Knee mal-alignment angle (per degree) 191 0.03 (-0.53 to 0.59) 0.924 173 -0.04 (-0.13 to 0.04) 0.291
  1. KOOS Knee Injury and Osteoarthritis Outcome Score, VAS visual analogue scale, MRI magnetic resonance imaging, WORMS Whole Organ Magnetic Resonance Imaging Score, KL Kellgren-Lawrence, JSN joint space narrowing. Results shown are from fixed panel regression. amaximal KL grade of the tibiofemoral or patellofemoral joint; bmaximal JSN score of the lateral or medial tibiofemoral or patellofemoral joint; cKOOS pain score ranges from 0–100 with lower scores representing more severe pain. Negative coefficients signify that more severe imaging findings were associated with less pain improvement; dpain on nominated activity ranged from 0 to 10 with higher values representing more severe pain. Positive coefficients signify that more severe imaging findings were associated with less pain improvement. *Represent results that are significant at p < 0.05