Fig. 1
From: Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
Hypothetical schematic of the physiological and pathophysiological roles of Notch signalling in articular cartilage. In mature chondrocytes, activation of the Notch–Rbpj–Hes1 pathway induces expression of catabolic and inflammation-related factors and enhances osteoarthritis (OA) development. Although Jag1 expression is abundant and increased with OA progression, the mechanisms underlying Notch activation in mature chondrocytes remain unclear. In contrast, Notch signalling may contribute to maintenance of chondrocyte progenitors and consequent homeostasis of articular cartilage. Adamts5 A disintegrin and metallopeptidase with thrombospondin type 1 motif 5, CaMKII calcium/calmodulin-dependent protein kinase II, Hes hairy and enhancer of split, Hey hairy/enhancer-of-split related with YRPW motif, ICD intracellular domain, IL interleukin, IL1RL1IL-1 receptor-like 1, Jag Jagged, Mmp matrix metalloproteinase, Rbpj recombination signal binding protein for Ig kappa J