Fig. 5
From: Tie2 as a novel key factor of microangiopathy in systemic sclerosis
Expression of Ang/Tie2 in dermal microvessels of bleomycin-challenged mice. a, b In bleomycin-treated mice, no significant difference in the expression of Ang-2 or Ang-1 (brown staining) could be observed in dermal microvessels (vWF positive; blue staining) compared with saline-treated controls. Vessels are indicated by arrows. c The percentage of mbTie2 positive (brown staining) dermal microvessels (vWF positive; blue staining) was significantly higher in bleomycin- vs. saline-treated mice. Vessels are indicated by arrows. Pictures are representative examples of four bleomycin-treated and four saline-treated controls. Ang Angiopoietin, HPF high power field, vWF von Willebrand factor, wt wildtype