ANCA-associated vasculitides | Other autoimmune diseases | |||
---|---|---|---|---|
GPA and MPA | EGPA | RA | CTD | |
Patients, n | 55 | 11 | 35 | 19 |
Female/male, n | 24/31 | 4/7 | 20/15 | 15/4 |
Age at RTX treatment, years | 56.2 (47.6–66.5) | 54.4 (37.0–62.2) | 59.0 (51.0–66.0) | 53.0 (46.0–69.0) |
Body mass index | 26.6 (21.9–29.4) | 25 (19.6–28.2) | 26.6 (21.5–30.4) | 24.1 (20.2–27.5) |
Autoantibodies | ANCA (100%) | ANCA (36%) | RF (94%) | ANA (100%) |
anti-PR3 (89%) | anti-PR3 (0%) | anti-CCP (94%) | ||
anti-MPO (9.1%) | anti-MPO (36%) | |||
Rituximab (one course) | ||||
RTX dose, g | 2.0 (2.0–2.86) | 2.0 (2.0–2.0) | 2.0 (1.0–2.0) | 2.0 (2.0–3.0) |
2 × 1000 mg, n (%) | 41 (75) | 11 (100) | 27 (77) | 15 (79) |
4 × 375 mg/m2, n (%) | 14 (25) | 0 (0) | 0 (0) | 1 (3) |
Other regimen, n (%) | 0 (0) | 0 (0) | 8 (23) | 3 (16) |
Rituximab (two courses) | ||||
patients, n (%) | 44 (80) | 8 (73) | 22 (63) | 8 (42) |
Mean time (± SEM) between first and second RTX course (months) | 25.5 (±3.1) | 19.3 (±4.8) | 20.5 (±3.6) | 19 (±3.9) |
Cyclophosphamide | ||||
cumulative dose (g) | 8.8 (3.5–25.0)† | 7.1 (0.0–9.8)† | 0.0 (0.0–0.0) | 4.5 (0.0–7.7)† |
Min. to max. (g) | 0.0–216.0 | 0.0–12.0 | 0.0–17.5 | 0.0–10.0 |
Pat. without CYC, n (%) | 8 (14.5) | 3 (27.3) | 30 (85,7) | 6 (31.6) |
Current (previous) concomitant immunosuppressive treatment, n | ||||
No DMARD, n | 13 (19) | 0 (1) | 7 (0) | 1 (2) |
PRED, n | 55 (55) | 11 (11) | 32 (35) | 18 (19) |
cumulative dose (g) | 2.28 (1.72–2.66)** | 3.63 (2.88–4.62) | 1.8 (1.73–2.52)** | 2.7 (1.8–3.24)* |
Min. to max. (g) | 0.46-3.73 | 2.22–5.02 | 0–5.85 | 0–10.8 |
MTX, n | 10 (22) | 1 (5) | 16 (29) | 3 (6) |
cumulative dose (g) | 0.78 (0.78–0.78) | 0.78 (0.78–0.78) | 0.78 (0.39–0.88) | 0.78 (0.78–0.78) |
Min. to max. (g) | 0.78–0.78 | 0.78–0.78 | 0.39–1.3 | 0.78–0.78 |
LEF, n | 11 (13) | 0 (1) | 5 (16) | 2 (3) |
cumulative dose (g) | 7.3 (7.3–7.3) | 0 | 7.3 (5.5–7.3) | 7.3 (7.3–7.3) |
Min. to max. (g) | 7.3-7.3 | 0 | 3.7-7.3 | 7.3-7.3 |
AZA, n | 15 (15) | 9 (8) | 0 (1) | 2 (9) |
cumulative dose (g) | 36.5 (36.5–54.8) | 54.7 (45.6–63.9) | 0 | 36.5 (36.5–36.5) |
Min. to max. (g) | 27.4–54.8 | 36.5–73 | 0 | 36.5–36.5 |
MMF, n | 6 (3) | 1 (1) | 0 (2) | 8 (11) |
cumulative dose (g) | 35.6 (35.6–71.2) | 35.6 (35.6–35.6) | 0 | 73 (66.2–73) |
Min. to max. (g) | 35.6–71.2 | 35.6–35.6 | 0 | 36.5– |
HCQ, n | 0 (1) | 0 (0) | 8 (13) | 9 (9) |
cumulative dose (g) | 0 | 0 | 73 (73–73) | 73 (73–73) |
Min. to max. (g) | 0 | 0 | 73–73 | 73–73 |