Fig. 3

Network graph showing associations between proteins encoded by genes with contrasting changes in expression from the pre-pregnancy baseline to the third trimester between RA women who improved and those who worsened. The nodes in the network represent proteins encoded by genes. The edges represent known as well as predicted interactions between the proteins, suggesting that they are part of a common functional network. Proteins that were not joined in the network are not shown. Variations at the levels of transcripts or post-translational modification are also not shown. Nodes with unknown 3D structure are shown by smaller size