Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

Table 4 Association between baseline systemic bone mineral density and annual percentage tibial cartilage volume loss

	Univariable analysis Regression coefficient (95% CI)	P	Multivariable analysis^a Regression coefficient (95% CI)	P
Total body BMD
Medial	0.02 (−0.26, 0.30)	0.90	0.16 (−0.21, 0.52)	0.40
Lateral	0.22 (0.01, 0.43)	0.04	0.44 (0.17, 0.71)	0.002
Spine BMD
Medial	0.003 (−0.16, 0.17)	0.98	0.03 (−0.15, 0.20)	0.75
Lateral	0.14 (0.01, 0.26)	0.03	0.17 (0.04, 0.30)	0.01
Total hip BMD
Medial	0.01 (−0.17, 0.18)	0.95	0.07 (−0.15, 0.29)	0.53
Lateral	0.16 (0.03, 0.30)	0.02	0.29 (0.13, 0.45)	0.001

Bone mineral density (BMD) was assessed in g/10 cm² so that one unit change in BMD approximated one standard deviation change in BMD. ^aAdjusted for gender, baseline age, body mass index, strenuous physical activity, and respective tibial bone area

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