Table 1 Comparison of clinical profile between patients with pSS + Fanconi syndrome and pSS + TIN
From: Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome
| Â | pSS with Fanconi syndrome | pSS with TIN | P value* |
|---|---|---|---|
(N = 12) | (N = 20) | ||
Age (years) | 39.3 ± 8.6 | 37.6 ± 12.2 | 0.366 |
Gender (female %) | 10 (83.3) | 18 (90.0) | 0.620 |
Presenting symptoms | |||
 Polyuria | 8 (66.7) | 10 (50.0) | 0.471 |
 Muscle weakness | 9 (75.0) | 14 (70.0) | 1.000 |
 Nocturia | 7 (58.3) | 5 (25.0) | 0.130 |
 dRTA | 9 (75.0) | 11 (55.0) | 0.452 |
 Paralysis | 3 (25.0) | 6 (30.0) | 1.000 |
 SCr elevation | 9 (75.0) | 12 (60.0) | 0.465 |
 eGFR (ml/min/1.73 m2) | 66.08 ± 38.20 | 76.14 ± 39.57 | 0.716 |
 Serum potassium (mmol/L) | 2.79 ± 0.14 | 2.76 ± 0.24 | 0.120 |
 Serum calcium (mmol/L) | 2.23 ± 0.14 | 2.13 ± 0.09 | 0.104 |
 Serum phosphorus (mmol/L) | 0.69 ± 0.33 | 1.02 ± 0.29 | 0.001 |
 24-h urine protein (g/24 h) | 1.51 ± 0.84 | 1.00 ± 0.61 | 0.019 |
Systemic manifestations | |||
 ESSDAI | 18.83 ± 7.83 | 15.50 ± 6.53 | 0.289 |
 Weight loss (>5%) | 7 (58.3) | 6 (30.0) | 0.150 |
 Glandular | 2 (16.7) | 3 (15.0) | 1.000 |
 Cutaneous | 1 (8.3) | 1 (5.0) | 1.000 |
 Pulmonary | 1 (8.3) | 3 (15.0) | 1.000 |
 Lymphadenopathy | 0 (0.0) | 2 (10.0) | 0.516 |
 HGB (g/L) | 105.3 ± 25.2 | 113.4 ± 13.6 | 0.408 |
Immune profile | |||
 ESR (mm/h) | 58.8 ± 30.9 | 42.7 ± 30.9 | 0.141 |
 ANA positive | 9 (75.0) | 18 (90.0) | 0.338 |
 SSA positive | 5 (41.7) | 14 (73.7) | 0.130 |
 SSB positive | 3 (25.0) | 19 (47.1) | 0.273 |
 IgG (g/L) | 18.3 ± 8.2 | 19.7 ± 6.3 | 0.588 |