Skip to main content

Table 1 Comparison of clinical profile between patients with pSS + Fanconi syndrome and pSS + TIN

From: Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome

  pSS with Fanconi syndrome pSS with TIN P value*
(N = 12) (N = 20)
Age (years) 39.3 ± 8.6 37.6 ± 12.2 0.366
Gender (female %) 10 (83.3) 18 (90.0) 0.620
Presenting symptoms
 Polyuria 8 (66.7) 10 (50.0) 0.471
 Muscle weakness 9 (75.0) 14 (70.0) 1.000
 Nocturia 7 (58.3) 5 (25.0) 0.130
 dRTA 9 (75.0) 11 (55.0) 0.452
 Paralysis 3 (25.0) 6 (30.0) 1.000
 SCr elevation 9 (75.0) 12 (60.0) 0.465
 eGFR (ml/min/1.73 m2) 66.08 ± 38.20 76.14 ± 39.57 0.716
 Serum potassium (mmol/L) 2.79 ± 0.14 2.76 ± 0.24 0.120
 Serum calcium (mmol/L) 2.23 ± 0.14 2.13 ± 0.09 0.104
 Serum phosphorus (mmol/L) 0.69 ± 0.33 1.02 ± 0.29 0.001
 24-h urine protein (g/24 h) 1.51 ± 0.84 1.00 ± 0.61 0.019
Systemic manifestations
 ESSDAI 18.83 ± 7.83 15.50 ± 6.53 0.289
 Weight loss (>5%) 7 (58.3) 6 (30.0) 0.150
 Glandular 2 (16.7) 3 (15.0) 1.000
 Cutaneous 1 (8.3) 1 (5.0) 1.000
 Pulmonary 1 (8.3) 3 (15.0) 1.000
 Lymphadenopathy 0 (0.0) 2 (10.0) 0.516
 HGB (g/L) 105.3 ± 25.2 113.4 ± 13.6 0.408
Immune profile
 ESR (mm/h) 58.8 ± 30.9 42.7 ± 30.9 0.141
 ANA positive 9 (75.0) 18 (90.0) 0.338
 SSA positive 5 (41.7) 14 (73.7) 0.130
 SSB positive 3 (25.0) 19 (47.1) 0.273
 IgG (g/L) 18.3 ± 8.2 19.7 ± 6.3 0.588
  1. Data presented as number (%) or mean ± SD unless otherwise noted
  2. ANA antinuclear antibody, dRTA distal renal tubule acidosis, eGFR estimated glomerular filtration rate, ESR erythrocyte sedimentation rate, ESSDAI Eular Sjogren’s Syndrome Disease Activity Index, HGB hemoglobin, IgG immunoglobulin G, pSS primary Sjogren syndrome, SCr serum creatinine, SSA Sjogren-syndrome-related antigen A, SSB Sjogren-syndrome-related antigen B, TIN tubulointerstitial nephritis
  3. *Mann–Whitney (two-tailed) test for continuous variables and Fisher’s exact (two-tailed) test for categorical variables