Fig. 4
From: Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis
Mean ± SD ng/mg of etanercept in lymph nodes (LNs) with the greatest radioactivity in animals 12 and 36 h following etanercept administration via intravenous (IV), intradermal (ID), subcutaneous (SC), and SOFUSATM administration. Values of etanercept concentration following systemic IV administration represent the mean ± standard deviation of all LNs harvested. Values of etanercept concentration following ID, SC and SOFUSATM administration represent the mean ± standard deviation of the most radioactive LN harvested from each animal. Two-tailed p values denote significant differences between etanercept LN concentrations at 36 h following administration via the SOFUSATM, IV, ID, and SC routes