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Table 3 Multivariate p values to assess the differences in swelling and lymphatic pumping function at days 11, 13, and 18 in animals with etanercept administered by SOFUSA™ and the SC and ID routes and in untreated animals

From: Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis

  ID SC Untreated
Day 11 (overall, p = 0.62)
 SOFUSA™ 0.17 0.43 0.84
 ID   0.70 0.35
 SC    0.76
Day 13 (overall, p = 0.0002)
 SOFUSA™ 0.07 0.39 <0.0001
 ID   0.69 0.0017
 SC    0.0015
Day 18 (overall, p <0.0001)
 SOFUSA™ 0.48 0.10 <0.0001
 ID   0.13 0.0006
 SC    0.004
  1. ID intradermal, SC subcutaneous. P < 0.008 is statistically significant due to application of the Bonferroni adjustment for multiple comparisons