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Table 1 Ex-vivo tissue distribution of [18F]fluoro-PEG-folate in various tissues of healthy control, 2 × -MTX and 4 × -MTX rats at 60 min post tracer injection

From: In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography

Tissue Healthy rats Control rats 2 × -MTX group 4 × -MTX group
Bone 0.103 ± 0.040 0.134 ± 0.022 0.064 ± 0.011 0.032 ± 0.016
Plasma 0.013 ± 0.007 0.010 ± 0.006 0.009 ± 0.002 0.010 ± 0.001
Blood 0.007 ± 0.009 0.007 ± 0.001 0.005 ± 0.002 0.006 ± 0.001
Lung 0.051 ± 0.019 0.074 ± 0.024 0.025 ± 0.016 0.024 ± 0.005
Heart 0.045 ± 0.015 0.080 ± 0.028 0.034 ± 0.004 0.022 ± 0.006
Liver 0.081 ± 0.049 0.106 ± 0.041 0.053 ± 0.006 0.042 ± 0.01
Spleen 0.393 ± 0.131 0.551 ± 0.218 0.132 ± 0.027 0.062 ± 0.034
Kidney 3.106 ± 0.317 2.077 ± 0.895 3.386 ± 0.186 3.098 ± 0.612
Skin 0.116 ± 0.017 0.138 ± 0.025 0.090 ± 0.012 0.063 ± 0.027
  1. Results expressed as mean percentage injected dose per gram (%ID/g) ± standard deviation
  2. MTX methotrexate