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Table 1 Ex-vivo tissue distribution of [18F]fluoro-PEG-folate in various tissues of healthy control, 2 × -MTX and 4 × -MTX rats at 60 min post tracer injection

From: In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography

Tissue

Healthy rats

Control rats

2 × -MTX group

4 × -MTX group

Bone

0.103 ± 0.040

0.134 ± 0.022

0.064 ± 0.011

0.032 ± 0.016

Plasma

0.013 ± 0.007

0.010 ± 0.006

0.009 ± 0.002

0.010 ± 0.001

Blood

0.007 ± 0.009

0.007 ± 0.001

0.005 ± 0.002

0.006 ± 0.001

Lung

0.051 ± 0.019

0.074 ± 0.024

0.025 ± 0.016

0.024 ± 0.005

Heart

0.045 ± 0.015

0.080 ± 0.028

0.034 ± 0.004

0.022 ± 0.006

Liver

0.081 ± 0.049

0.106 ± 0.041

0.053 ± 0.006

0.042 ± 0.01

Spleen

0.393 ± 0.131

0.551 ± 0.218

0.132 ± 0.027

0.062 ± 0.034

Kidney

3.106 ± 0.317

2.077 ± 0.895

3.386 ± 0.186

3.098 ± 0.612

Skin

0.116 ± 0.017

0.138 ± 0.025

0.090 ± 0.012

0.063 ± 0.027

  1. Results expressed as mean percentage injected dose per gram (%ID/g) ± standard deviation
  2. MTX methotrexate