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Table 4 PFH of diseases in first- or second-degree relatives of CBP patients meeting the ASAS axSpA criteria, stratified according to HLA-B27 status

From: Is the current ASAS expert definition of a positive family history useful in identifying axial spondyloarthritis? Results from the SPACE and DESIR cohorts

Positive family history SPACE cohort n = 201* DESIR cohort n = 409**
  HLA-B27+ HLA-B27– HLA-B27+ HLA-B27–
Any PFH 90 (45%) 14 (7%) 145 (35%) 24 (6%)
AS 59 (29%) 2 (1%) 92 (23%) 5 (1%)
AAU 22 (11%) 1 (1%) 26 (6%) 0 (0)
ReA 4 (1%) 1 (1%) 1 (0.2%) 1 (0.2%)
IBD 11 (6%) 5 (3%) 14 (3%) 5 (1%)
Psoriasis 32 (16%) 9 (5%) 65 (16%) 20 (5%)
  1. *Two hundred and three patients fulfilled ASAS-criteria, two with unknown HLA-B27 status
  2. **Four hundred and ten patients fulfilled ASAS-criteria, one with unknown HLA-B27 status
  3. AAU acute anterior uveitis, AS ankylosing spondylitis, ASAS axSpA Assessment of Spondyloarthritis international Society criteria for axial spondyloarthritis, HLA-B27 human leucocyte antigen B27, IBD inflammatory bowel disease, PFH postitive family history (manifestation in first- or second-degree relatives), ReA reactive arthritis