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Table 4 PFH of diseases in first- or second-degree relatives of CBP patients meeting the ASAS axSpA criteria, stratified according to HLA-B27 status

From: Is the current ASAS expert definition of a positive family history useful in identifying axial spondyloarthritis? Results from the SPACE and DESIR cohorts

Positive family history

SPACE cohort n = 201*

DESIR cohort n = 409**

 

HLA-B27+

HLA-B27–

HLA-B27+

HLA-B27–

Any PFH

90 (45%)

14 (7%)

145 (35%)

24 (6%)

AS

59 (29%)

2 (1%)

92 (23%)

5 (1%)

AAU

22 (11%)

1 (1%)

26 (6%)

0 (0)

ReA

4 (1%)

1 (1%)

1 (0.2%)

1 (0.2%)

IBD

11 (6%)

5 (3%)

14 (3%)

5 (1%)

Psoriasis

32 (16%)

9 (5%)

65 (16%)

20 (5%)

  1. *Two hundred and three patients fulfilled ASAS-criteria, two with unknown HLA-B27 status
  2. **Four hundred and ten patients fulfilled ASAS-criteria, one with unknown HLA-B27 status
  3. AAU acute anterior uveitis, AS ankylosing spondylitis, ASAS axSpA Assessment of Spondyloarthritis international Society criteria for axial spondyloarthritis, HLA-B27 human leucocyte antigen B27, IBD inflammatory bowel disease, PFH postitive family history (manifestation in first- or second-degree relatives), ReA reactive arthritis
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Arthritis Research & Therapy

ISSN: 1478-6362

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