IFN-λ1 with Th17 axis cytokines and IFN-α define different subsets in systemic lupus erythematosus (SLE)

Table 2 Correlations between the levels of investigated cytokines in patients with systemic lupus erythematosus

Cytokine	IFN-λ1	IL-23	IL-17A	IP-10	IFN-α
IFN-λ1	–	ρ = 0.57 p < 0.0001	ρ = 0.50 p < 0.0001	ρ = 0.175 p = 0.005	ns
IL-23	ρ = 0.57 p < 0.0001	–	ρ = 0.47 p < 0.0001	ρ = 0.21 p = 0.0007	ρ = 0.16 p = 0.01
IL-17A	ρ = 0.51 p < 0.0001	ρ = 0.47 p < 0.0001	–	ρ = 0.2 p = 0.0007	ns
IP-10	ρ = 0.175 p = 0.005	ρ = 0.21 p = 0.0007	ρ = 0.2 p = 0.0007	–	ns
SLAM	ns	ns	ns	ρ = 0.16 p = 0.01	ns
SLEDAI	ns	ns	ρ = -0.13 p = 0.037	ρ = 0.21 p = 0.0007	ns
SDI	ns	ns	ns	ρ = 0.13 p = 0.047	ρ = −0.14 p = 0.028

Abbreviations: IFN Interferon, IL Interleukin, IP-10 Interferon-γ-induced protein 10, ns Nonsignificant, SDI Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, SLAM Systemic Lupus Activity Measure, SLEDAI Systemic Lupus Erythematosus Disease Activity Index
Statistical analysis was performed by Spearman’s rank correlation test

ISSN: 1478-6362