Arthritis Research & Therapy

Table 2 Glycosylation comparison of healthy control subjects vs. patients with rheumatoid arthritis at the non-pregnant state (≥26 weeks after delivery)

From: IgA N- and O-glycosylation profiling reveals no association with the pregnancy-related improvement in rheumatoid arthritis

				Healthy		RA		p Value
				Mean	SEM	Mean	SEM	p Value
O-glycosylation			GalNAc, n	4.81	0.009	4.82	0.004	0.230
			Gal, n	3.99	0.014	4.03	0.005	0.017
			SAs, n	3.05	0.027	3.15	0.013	0.002
			SAs per Gal	0.76	0.006	0.78	0.003	0.007
			Gals per GalNAc	0.83	0.003	0.84	0.001	0.028
N-glycosylation	Asn144		% Sialylation	60.37	0.854	58.09	0.388	0.039
	Asn144		% Bisection	26.27	0.784	32.04	0.604	<0.001
	Asn340	Intact	% Sialylation	95.68	0.170	95.17	0.106	0.097
		Trunc.	% Sialylation	89.82	0.173	90.13	0.086	0.104
		Intact	% Bisection	57.94	1.057	60.45	0.508	0.046
		Trunc.	% Bisection	56.12	0.893	57.26	0.444	0.355
		Trunc.	% Fucosylation	93.57	0.304	92.98	0.134	0.055
		Trunc.	% Triantennary	5.30	0.298	4.97	0.119	0.136

Abbreviations: Gal Galactose, GalNAc N-acetylgalactosamine, RA Rheumatoid arthritis, SA Sialic acid, trunc. Truncated
Bonferroni-corrected p < 0.004 is considered significant, indicated by boldface type

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