| |
Healthy
|
RA
|
p Value
|
|---|
|
Mean
|
SEM
|
Mean
|
SEM
|
|---|
|
O-glycosylation
|
GalNAc, n
|
4.81
|
0.009
|
4.82
|
0.004
|
0.230
|
|
Gal, n
|
3.99
|
0.014
|
4.03
|
0.005
|
0.017
|
|
SAs, n
|
3.05
|
0.027
|
3.15
|
0.013
|
0.002
|
|
SAs per Gal
|
0.76
|
0.006
|
0.78
|
0.003
|
0.007
|
|
Gals per GalNAc
|
0.83
|
0.003
|
0.84
|
0.001
|
0.028
|
|
N-glycosylation
|
Asn144
|
% Sialylation
|
60.37
|
0.854
|
58.09
|
0.388
|
0.039
|
|
% Bisection
|
26.27
|
0.784
|
32.04
|
0.604
|
<0.001
|
|
Asn340
|
Intact
|
% Sialylation
|
95.68
|
0.170
|
95.17
|
0.106
|
0.097
|
|
Trunc.
|
89.82
|
0.173
|
90.13
|
0.086
|
0.104
|
|
Intact
|
% Bisection
|
57.94
|
1.057
|
60.45
|
0.508
|
0.046
|
|
Trunc.
|
56.12
|
0.893
|
57.26
|
0.444
|
0.355
|
|
Trunc.
|
% Fucosylation
|
93.57
|
0.304
|
92.98
|
0.134
|
0.055
|
|
Trunc.
|
% Triantennary
|
5.30
|
0.298
|
4.97
|
0.119
|
0.136
|
-
Abbreviations: Gal Galactose, GalNAc N-acetylgalactosamine, RA Rheumatoid arthritis, SA Sialic acid, trunc. Truncated
- Bonferroni-corrected p < 0.004 is considered significant, indicated by boldface type
