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Table 2 Glycosylation comparison of healthy control subjects vs. patients with rheumatoid arthritis at the non-pregnant state (≥26 weeks after delivery)

From: IgA N- and O-glycosylation profiling reveals no association with the pregnancy-related improvement in rheumatoid arthritis

  Healthy RA p Value
Mean SEM Mean SEM
O-glycosylation GalNAc, n 4.81 0.009 4.82 0.004 0.230
Gal, n 3.99 0.014 4.03 0.005 0.017
SAs, n 3.05 0.027 3.15 0.013 0.002
SAs per Gal 0.76 0.006 0.78 0.003 0.007
Gals per GalNAc 0.83 0.003 0.84 0.001 0.028
N-glycosylation Asn144 % Sialylation 60.37 0.854 58.09 0.388 0.039
% Bisection 26.27 0.784 32.04 0.604 <0.001
Asn340 Intact % Sialylation 95.68 0.170 95.17 0.106 0.097
Trunc. 89.82 0.173 90.13 0.086 0.104
Intact % Bisection 57.94 1.057 60.45 0.508 0.046
Trunc. 56.12 0.893 57.26 0.444 0.355
Trunc. % Fucosylation 93.57 0.304 92.98 0.134 0.055
Trunc. % Triantennary 5.30 0.298 4.97 0.119 0.136
  1. Abbreviations: Gal Galactose, GalNAc N-acetylgalactosamine, RA Rheumatoid arthritis, SA Sialic acid, trunc. Truncated
  2. Bonferroni-corrected p < 0.004 is considered significant, indicated by boldface type
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Arthritis Research & Therapy

ISSN: 1478-6362

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