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Fig. 8 | Arthritis Research & Therapy

Fig. 8

From: High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

Fig. 8

Effects of high compression on reactive oxygen species (ROS) generation, p38 MAPK activity, senescence phenotype and matrix homeostatic phenotype of nucleus pulposus (NP) cells in rat disc organ culture. The results showed that high compression (1.3 MPa) increased ROS generation (a), upregulated p38 MAPK activation (b), promoted the senescence phenotype (c), and inhibited matrix homeostatic phenotype (d-f) of NP cells compared with low compression (0.1 MPa). Data are expressed as the mean ± SD (n = 3). *Indicates a significant difference (p < 0.05) between the two groups. GAG glycosaminoglycan, RFU relative fluorescence units

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