Table 1 GSEA of selected pathways on the basis of OA-related functions from chondrocytes transduced with ADV-LOXL2 compared to empty vector (control)
Name | Size | NES | Nom P value | FDR q value |
|---|---|---|---|---|
Reactome cell cycle checkpoints | 109 | −2.478 | 0.0001 | 0.00 |
Reactome activation of genes by ATF4 | 24 | −2.234 | 0.000 | 0.00 |
Reactome SMAD2 SMAD3 SMAD4 heterotrimer regulates transcription | 25 | −1.880 | 0.002 | 0.01 |
Reactome signaling by TGF Beta receptor complex | 59 | −1.748 | 0.0001 | 0.03 |
Reactome MAPK targets nuclear events mediated by MAP kinases | 30 | −1.620 | 0.010 | 0.07 |
ttccgtt, MIR-191 | 29 | −1.604 | 0.012 | 0.07 |
Cell proliferation GO 0008283 | 495 | −1.578 | 0.000 | 0.08 |
Biocarta TNFR1 pathway | 29 | −1.533 | 0.033 | 0.11 |
Negative regulation of cell proliferation | 153 | −1.508 | 0.002 | 0.12 |
aagcact, MIR-520 F | 238 | −1.493 | 0.000 | 0.13 |
Regulation of angiogenesis | 26 | −1.476 | 0.061 | 0.14 |
Reactome muscle contraction | 46 | 2.023 | 0.0001 | 0.19 |
Regulation of apoptosis | 332 | −1.373 | 0.006 | 0.21 |
Regulation of cell proliferation | 298 | −1.371 | 0.010 | 0.21 |
IĸB kinase NF-ĸB cascade | 109 | −1.36 | 0.06 | 0.23 |
Vasculature development | 55 | −1.346 | 0.072 | 0.24 |
Reactome platelet calcium homeostasis | 16 | 1.768 | 0.001 | 0.24 |
Reactome antigen activates b cell receptor leading to the generation of second messengers | 29 | 1.750 | 0.001 | 0.24 |
Negative regulation of developmental process | 189 | −1.335 | 0.022 | 0.25 |