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Table 1 GSEA of selected pathways on the basis of OA-related functions from chondrocytes transduced with ADV-LOXL2 compared to empty vector (control)

From: Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis

Name Size NES Nom P value FDR q value
Reactome cell cycle checkpoints 109 −2.478 0.0001 0.00
Reactome activation of genes by ATF4 24 −2.234 0.000 0.00
Reactome SMAD2 SMAD3 SMAD4 heterotrimer regulates transcription 25 −1.880 0.002 0.01
Reactome signaling by TGF Beta receptor complex 59 −1.748 0.0001 0.03
Reactome MAPK targets nuclear events mediated by MAP kinases 30 −1.620 0.010 0.07
ttccgtt, MIR-191 29 −1.604 0.012 0.07
Cell proliferation GO 0008283 495 −1.578 0.000 0.08
Biocarta TNFR1 pathway 29 −1.533 0.033 0.11
Negative regulation of cell proliferation 153 −1.508 0.002 0.12
aagcact, MIR-520 F 238 −1.493 0.000 0.13
Regulation of angiogenesis 26 −1.476 0.061 0.14
Reactome muscle contraction 46 2.023 0.0001 0.19
Regulation of apoptosis 332 −1.373 0.006 0.21
Regulation of cell proliferation 298 −1.371 0.010 0.21
IĸB kinase NF-ĸB cascade 109 −1.36 0.06 0.23
Vasculature development 55 −1.346 0.072 0.24
Reactome platelet calcium homeostasis 16 1.768 0.001 0.24
Reactome antigen activates b cell receptor leading to the generation of second messengers 29 1.750 0.001 0.24
Negative regulation of developmental process 189 −1.335 0.022 0.25
  1. A positive NES indicates that the genes in the set are predominantly upregulated with respect to the reference group, and a negative NES indicates that the genes in the set are predominantly downregulated with respect to the reference group. GSEA gene set enrichment analysis, OA osteoarthritis, FDR false discovery rate, MAP mitogen-activated protein, TGF transforming growth factor