Table 3 ORs [95% CIs] and P values for hyperuricaemia single-nucleotide polymorphisms

  Rs2231142 (ABCG2)

T

G

2.10 [2.10–2.45], 2.38 × 10⁻⁹²

2.29 [2.10–2.50], 4.22 × 10⁻⁷⁷

2.10 [1.76–2.52], 3.57 × 10⁻¹⁶

2.18 [2.00–2.37], 4.47 × 10⁻⁷⁴

2.22 [2.06–2.40], 1.93 × 10⁻⁹⁵

  Rs12498742 (SLC2A9)

A

G

1.80 [1.65–1.97], 6.14 × 10⁻³⁹

1.81 [1.64–2.00], 4.75 × 10⁻³²

1.75 [1.43–2.14], 4.12 × 10⁻⁸

1.79 [1.63–1.97], 8.22 × 10⁻³⁵

1.81 [1.67–1.97], 1.00 × 10⁻⁴³

  Rs1260326 (GCKR)

T

C

1.31 [1.23–1.40], 2.22 × 10⁻¹⁷

1.26 [1.18–1.36], 9.30 × 10⁻¹¹

1.33 [1.15–1.53], 0.00010

1.26 [1.18–1.35], 6.47 × 10⁻¹²

1.28 [1.21–1.36], 4.63 × 10⁻¹⁶

  Rs1165151 (SLC17A3)

T

G

0.83 [0.78–0.88], 5.36 × 10⁻⁹

0.83 [0.77–0.89], 1.47 × 10⁻⁷

0.94 [0.81–1.08], 0.38

0.83 [0.77–0.89], 4.43 × 10⁻⁸

0.82 [0.77–0.87], 7.87 × 10⁻¹¹

  Rs478607 (SLC22A12)

A

G

0.79 [0.73–0.86], 2.32 × 10⁻⁸

0.78 [0.71–0.85], 5.42 × 10⁻⁸

0.87 [0.71–1.05], 0.14

0.79 [0.73–0.87], 2.18 × 10⁻⁷

0.79 [0.73–0.85], 2.00 × 10⁻⁹

  Rs1471633 (PDZK1)

A

C

1.18 [1.11–1.26], 2.60 × 10⁻⁷

1.19 [1.10–1.28], 2.25 × 10⁻⁶

1.05 [0.91–1.21], 0.50

1.18 [1.10–1.26], 1.54 × 10⁻⁶

1.17 [1.11–1.25], 1.86 × 10⁻⁷

  Rs3741414 (INHBE)

A

G

0.83 [0.76–0.89], 9.86 × 10⁻⁷

0.83 [0.76–0.91], 2.38 × 10⁻⁵

0.80 [0.67–0.95], 0.013

0.844 [0.78–0.92], 3.96 × 10⁻⁵

0.84 [0.78–0.90], 2.81 × 10⁻⁶

  Rs1171614 (SLC16A9)

T

C

0.82 [0.76–0.89], 1.11 × 10⁻⁶

0.86 [0.79–0.94], 0.00053

0.88 [0.74–1.05], 0.15

0.87 [0.81–0.95], 0.0012

0.84 [0.78–0.91], 4.78 × 10⁻⁶

  Rs2078267 (SLC22A11)

T

C

0.87 [0.82–0.93], 1.61 × 10⁻⁵

0.86 [0.80–0.92], 1.86 × 10⁻⁵

0.85 [0.74–0.98], 0.026

0.87 [0.81–0.93], 1.97 × 10⁻⁵

0.86 [0.81–0.91], 5.18 × 10⁻⁷

  Rs675209 (RREB1)

T

C

1.10 [1.03–1.18], 0.0056

1.10 [1.02–1.19], 0.017

0.98 [0.83–1.15], 0.80

1.09 [1.01–1.17], 0.024

1.09 [1.02–1.17], 0.0078

  Rs11264341 (PKLR)

T

C

0.88 [0.83–0.94], 0.00013

0.89 [0.83–0.96], 0.0018

0.93 [0.81–1.08], 0.35

0.89 [0.83–0.95], 0.0004

0.87 [0.82–0.93], 1.18 × 10⁻⁵

  Rs17050272 (INHBB)

A

G

1.00 [0.94–1.07], 0.98

0.98 [0.91–1.05], 0.51

1.13 [0.97–1.30], 0.11

1.00 [0.93–1.07], 0.96

1.00 [0.94–1.06], 0.90

  Rs2307394 (ACVR2A)

T

C

0.97 [0.91–1.04], 0.40

1.00 [0.92–1.08], 0.96

0.96 [0.82–1.12], 0.57

0.97 [0.91–1.05], 0.47

0.97 [0.91–1.04], 0.39

  Rs6770152 (MUSTN1)

T

G

0.91 [0.85–0.97], 0.0042

0.93 [0.86–1.00], 0.04

0.93 [0.80–1.07], 0.31

0.92 [0.86–0.98], 0.015

0.91 [0.85–0.96], 0.0015

  Rs17632159 (TMEM171)

C

G

0.91 [0.85–0.98], 0.010

0.91 [0.84–0.99], 0.025

0.92 [0.79–1.08], 0.32

0.92 [0.85–0.99], 0.025

0.91 [0.85–0.97], 0.0064

  Rs729761 (VEGFA)

T

G

0.95 [0.89–1.02], 0.19

0.93 [0.86–1.01], 0.079

1.04 [0.88–1.22], 0.67

0.94 [0.87–1.01], 0.10

0.96 [0.89–1.03], 0.21

  Rs1178977 (MLXIPL)

A

G

1.19 [1.10–1.30], 3.49 × 10⁻⁵

1.14 [1.04–1.25], 0.0066

1.02 [0.85–1.22], 0.81

1.15 [1.05–1.25], 0.0020

1.18 [1.09–1.28], 3.79 × 10⁻⁵

  Rs10480300 (PRKAG2)

T

C

1.08 [1.01–1.16], 0.026

1.09 [1.01–1.18], 0.032

1.05 [0.89–1.23], 0.57

1.06 [0.99–1.14], 0.119

1.08 [1.01–1.15], 0.028

  Rs17786744 (STC1)

A

G

0.98 [0.92–1.05], 0.53

1.01 [0.94–1.08], 0.86

0.95 [0.82–0.10], 0.49

0.99 [0.93–1.06], 0.82

1.00 [0.94–1.06], 0.99

  Rs2941484 (HNF4G)

T

C

1.07 [1.00–1.14], 0.037

1.09 [1.01–1.17], 0.023

0.91 [0.78–1.06], 0.22

1.08 [1.00–1.15], 0.040

1.07 [1.01–1.14], 0.029

  Rs10821905 (ASAH2)

A

G

1.12 [1.04–1.22], 0.0049

1.08 [0.99–1.18], 0.10

0.97 [0.80–1.17], 0.73

1.09 [1.00–1.19], 0.051

1.11 [1.03–1.20], 0.0080

  Rs642803 (LTBP3)

T

C

0.92 [0.86–0.98], 0.011

0.92 [0.85–0.98], 0.016

0.90 [0.78–1.04], 0.16

0.90 [0.84–0.96], 0.0025

0.92 [0.87–0.89], 0.0090

  Rs653178 (PTPN11)

T

C

0.89 [0.83–0.94], 0.00015

0.87 [0.81–0.93], 0.00012

0.92 [0.79–1.06], 0.24

0.89 [0.83–0.95], 0.00061

0.88 [0.83–0.93], 3.11 × 10⁻⁵

  Rs1394125 (NRG4)

A

G

1.08 [1.01–1.15], 0.026

1.05 [0.98–1.30], 0.19

1.11 [0.96–1.29], 0.17

1.07 [0.99–1.14], 0.074

1.07 [1.01–1.14], 0.027

  Rs6598541 (IGF1R)

A

G

1.07 [1.00–1.40], 0.059

1.01 [0.94–1.09], 0.78

0.98 [0.84–1.14], 0.75

1.02 [0.95–1.10], 0.55

1.05 [0.99–1.12], 0.12

  Rs7193778 (NFAT5)

T

C

0.90 [0.83–0.98], 0.021

0.96 [0.87–1.06], 0.43

0.88 [0.72–1.07], 0.19

0.95 [0.86–1.04], 0.25

0.90 [0.83–0.97], 0.0087

  Rs7188445 (MAF)

A

G

0.99 [0.93–1.06], 0.87

1.01 [0.94–1.09], 0.82

0.96 [0.82–1.11], 0.56

1.00 [0.93–1.07], 0.95

1.00 [0.94–1.06], 0.94

  Rs7224610 (HLF)

A

C

0.93 [0.87–0.99], 0.022

0.92 [0.85–0.99], 0.022

0.95 [0.82–1.10], 0.51

0.94 [0.87–1.00], 0.058

0.92 [0.86–0.98], 0.0061

  Rs2079742 (C17ORF82)

T

C

1.07 [0.97–1.17], 0.18

1.09 [0.97–1.21], 0.14

1.07 [0.86–1.33], 0.54

1.08 [0.98–1.20], 0.13

1.06 [0.97–1.16], 0.23

  Rs164009 (PRPSAP1)

A

G

1.03 [0.96–1.09], 0.45

1.01 [0.94–1.09], 0.83

1.06 [0.91–1.23], 0.45

1.01 [0.94–1.08], 0.80

1.02 [0.96–1.09], 0.47

Number of loci associated with gout at genome wide significance

5

3

2

4

5

Number of loci associated with gout at experiment wide significance

12

10

3

11

13