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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity

Fig. 6

Late-phase toxic effects of Bz after treatment. Mice were injected with vehicle (18wk) or Bz twice a week beginning at 10 weeks (10wkBz-18wk) and 14 weeks (14wkBz–18wk) of age until 18 weeks of age. At 18 weeks of age, mice were sacrificed and the blood samples were analyzed. a Blood count analysis. b Renal and liver function test: Serum Cr, AST, and ALT. c Serum IFN-γ, IL-6, and TNF-α levels. Values expressed as median with quartile range. Statistical analysis performed using one-way ANOVA analyses with Turkey post-hoc test. ALT alanine aminotransferase, AST aspartate aminotransferase, Cr creatinine, Hb hemoglobin, IFN-γ interferon-gamma, IL-6 interleukin-6, Plt platelet, TNF-α tumor necrosis alpha, WBC white blood cell

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