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Table 3 Correlation of rheumatoid factor and anti-cyclic citrullinated peptide antibodies at baseline with serum infliximab levels

From: High titers of both rheumatoid factor and anti-CCP antibodies at baseline in patients with rheumatoid arthritis are associated with increased circulating baseline TNF level, low drug levels, and reduced clinical responses: a post hoc analysis of the RISING study

  Serum infliximab level
Week 2 Week 6 Week 10 Week 14
Rho p Value Rho p Value Rho p Value Rho p Value
Sex (0 = male, 1 = female) 0.302 < 0.0001 0.211 0.0002 0.190 0.0008 0.160 0.0049
Age 0.004 0.9381 0.064 0.2664 0.030 0.5965 0.004 0.9472
BMI 0.160 0.0049 0.054 0.3468 0.033 0.5620 −0.015 0.7946
Disease duration 0.098 0.0852 0.112 0.0490 0.106 0.0631 0.093 0.1022
NSAID usea −0.087 0.1303 −0.018 0.7588 −0.039 0.4941 −0.060 0.2964
Glucocorticoid usea −0.060 0.2908 −0.076 0.1822 −0.039 0.4920 −0.064 0.2635
DMARD (other than MTX) usea −0.027 0.6361 −0.022 0.7002 −0.007 0.9018 0.027 0.6386
Duration of MTX use 0.100 0.0809 0.109 0.0558 0.063 0.2690 0.071 0.2141
MTX dose −0.043 0.4554 −0.074 0.1946 −0.053 0.3550 −0.041 0.4730
Comorbiditya 0.063 0.2680 0.064 0.2626 0.118 0.0384 0.099 0.0823
DAS28-CRP −0.128 0.0246 −0.116 0.0430 −0.125 0.0290 −0.073 0.2002
Total modified Sharp score −0.049 0.3945 0.069 0.2271 0.059 0.3064 0.060 0.2979
HAQ −0.104 0.0699 −0.035 0.5398 −0.060 0.2994 −0.048 0.4027
MMP-3 −0.107 0.0608 −0.146 0.0103 −0.103 0.0726 −0.101 0.0783
IL-6 −0.114 0.0461 −0.085 0.1357 −0.025 0.6639 0.000 0.9948
TNF −0.150 0.0083 −0.163 0.0041 −0.169 0.0031 −0.158 0.0054
RF −0.192 0.0007 −0.188 0.0009 −0.201 0.0004 −0.222 < 0.0001
Anti-CCP −0.153 0.0071 −0.121 0.0344 −0.133 0.0195 −0.172 0.0025
  1. Abbreviations: BMI Body mass index, CCP Cyclic citrullinated peptide antibodies, DAS28-CRP Disease Activity Score in 28 joints based on C-reactive protein, HAQ Health Assessment Questionnaire, IL-6 Interleukin-6, MMP-3 Matrix metalloproteinase-3, MTX Methotrexate, NSAID Nonsteroidal anti-inflammatory drug, RF Rheumatoid factor, Rho Spearman’s rank correlation coefficient, TNF Tumor necrosis factor
  2. aCategories of response are 0 = no, 1 = yes