Arthritis Research & Therapy

Table 3 Correlation of rheumatoid factor and anti-cyclic citrullinated peptide antibodies at baseline with serum infliximab levels

From: High titers of both rheumatoid factor and anti-CCP antibodies at baseline in patients with rheumatoid arthritis are associated with increased circulating baseline TNF level, low drug levels, and reduced clinical responses: a post hoc analysis of the RISING study

	Serum infliximab level
	Week 2		Week 6		Week 10		Week 14
	Rho	p Value	Rho	p Value	Rho	p Value	Rho	p Value
Sex (0 = male, 1 = female)	0.302	< 0.0001	0.211	0.0002	0.190	0.0008	0.160	0.0049
Age	0.004	0.9381	0.064	0.2664	0.030	0.5965	0.004	0.9472
BMI	0.160	0.0049	0.054	0.3468	0.033	0.5620	−0.015	0.7946
Disease duration	0.098	0.0852	0.112	0.0490	0.106	0.0631	0.093	0.1022
NSAID use^a	−0.087	0.1303	−0.018	0.7588	−0.039	0.4941	−0.060	0.2964
Glucocorticoid use^a	−0.060	0.2908	−0.076	0.1822	−0.039	0.4920	−0.064	0.2635
DMARD (other than MTX) use^a	−0.027	0.6361	−0.022	0.7002	−0.007	0.9018	0.027	0.6386
Duration of MTX use	0.100	0.0809	0.109	0.0558	0.063	0.2690	0.071	0.2141
MTX dose	−0.043	0.4554	−0.074	0.1946	−0.053	0.3550	−0.041	0.4730
Comorbidity^a	0.063	0.2680	0.064	0.2626	0.118	0.0384	0.099	0.0823
DAS28-CRP	−0.128	0.0246	−0.116	0.0430	−0.125	0.0290	−0.073	0.2002
Total modified Sharp score	−0.049	0.3945	0.069	0.2271	0.059	0.3064	0.060	0.2979
HAQ	−0.104	0.0699	−0.035	0.5398	−0.060	0.2994	−0.048	0.4027
MMP-3	−0.107	0.0608	−0.146	0.0103	−0.103	0.0726	−0.101	0.0783
IL-6	−0.114	0.0461	−0.085	0.1357	−0.025	0.6639	0.000	0.9948
TNF	−0.150	0.0083	−0.163	0.0041	−0.169	0.0031	−0.158	0.0054
RF	−0.192	0.0007	−0.188	0.0009	−0.201	0.0004	−0.222	< 0.0001
Anti-CCP	−0.153	0.0071	−0.121	0.0344	−0.133	0.0195	−0.172	0.0025

Abbreviations: BMI Body mass index, CCP Cyclic citrullinated peptide antibodies, DAS28-CRP Disease Activity Score in 28 joints based on C-reactive protein, HAQ Health Assessment Questionnaire, IL-6 Interleukin-6, MMP-3 Matrix metalloproteinase-3, MTX Methotrexate, NSAID Nonsteroidal anti-inflammatory drug, RF Rheumatoid factor, Rho Spearman’s rank correlation coefficient, TNF Tumor necrosis factor
^aCategories of response are 0 = no, 1 = yes

Back to article page

ISSN: 1478-6362

Contact us

General enquiries: journalsubmissions@springernature.com