Fig. 4
From: HM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupus
HM71224 prevents skin lesion progression. Skin lesions were observed in vehicle-treated mice around the nose or eyes (arrows show representative skin lesions) (a, b) compared with HM71224-treated MRL/lpr mice (c, d). e Skin lesion severity score was 1.4 ± 0.5 (mean ± SEM) in vehicle-treated mice, whereas no skin lesions developed in HM71224-treated MRL/lpr mice (P < 0.001) at 28 weeks of age (n = 11 per vehicle-treated group, n = 12 per HM71224-treated group)