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Table 6 Comparison of the demographics between patients with AOSD with or without DRB1*15:01 or DR5

From: Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease

  DRB1*15:01 (+) DRB1*15:01 (-) P DR5 (+) DR5 (-) P
Number 29 58   23 64  
Female, n (%) 24 (82.7) 45 (77.5) 0.7789 20 (86.9) 49 (77.4) 0.2912
Age at onset (years) 46.6 ± 20.3 50.6 ± 19.6 0.3980 50.6 ± 20.5 48.1 ± 19.7 0.7469
Ferritin (ng/mL) 12818.5 ± 18292.9 10555.5 ± 16284.7 0.3657 12669.4 ± 16305.9 10802.9 ± 17224.9 0.3243
CRP (mg/dL) 11.9 ± 8.2 12.7 ± 8.3 0.6802 12.0 ± 9.2 12.6 ± 7.9 0.5068
ESR (mm(1 h)) 59.6 ± 25.3 75.4 ± 30.9 0.1289 67.4 ± 23.0 72.5 ± 32.5 0.9361
Liver dysfunction, n (%) 24 (82.7) 44 (75.8) 0.4630 19 (82.6) 49 (76.5) 0.5472
MAS, n (%) 10 (38.6) 13 (22.4) 0.2288 10 (43.4) 13 (20.3) 0.0307
Initial dose of PSL (mg/day) 43.8 ± 13.0 41.5 ± 11.7 0.4379 46.1 ± 10.9 40.3 ± 12.4 0.1184
Steroid pulse, n (%) 17 (58.6) 38 (65.5) 0.4987 19 (82.6) 36 (56.2) 0.0245
Immunosuppressant, n (%) 18 (57.6) 33 (56.8) 0.6442 15 (65.2) 36 (56.2) 0.4539
Biologics, n (%) 10 (38.6) 16 (27.5) 0.5077 6 (26.0) 20 (31.2) 0.6427
Polycyclic systemic type, n (%) 20 (68.9) 36 (62.0) 0.5266 18 (78.2) 38 (59.3) 0.1048
Monocyclic systemic type, n (%) 8 (27.5) 13 (22.4) 0.5951 4 (17.3) 17 (26.5) 0.3780
Chronic arthritis type, n (%) 4 (13.7) 8 (13.7) 1.0000 2 (8.6) 10 (15.6) 0.4085
Relapse, n (%) 14 (48.2) 26 (44.8) 0.7619 11 (47.8) 29 (45.3) 0.8357
  1. Association was tested between patients with adult onset Still’s disease (AOSD) with or without DRB1*15:01 or DR5 analyzed by the chi-squared test using 2 × 2 contingency tables or the Mann-Whitney U test. CRP C-reactive protein, ESR erythrocyte sedimentation rate, MAS macrophage activation syndrome, PSL prednisolone