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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model

Fig. 4

Local mRNA expression in the hind paws and forepaws was analyzed using the QuantiGene 2.0 Plex assay. Fold change in gene expression was compared to that in wild-type controls. a-h TNFɑ (a), IL-6 (b), interferon-γ (IFN-γ) (c), IL-4 (d), IL-23 (e), IL-17A (f), dickkopf-related protein 1 (Dkk1) (g), and sclerostin (SOST) (h). Data are expressed as the average fold change relative to the wild-type control group. Values are mean ± SEM; n = 12 mice per group except for the wild-type control (n = 2); *P < 0.05, **P < 0.01, ***P < 0.001, versus controls. Sham = sham-operated mice, OVx = ovariectomized mice, OVx + E2 = 17β-estradiol-treated ovariectomized mice

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