Fig. 4
From: Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model
Local mRNA expression in the hind paws and forepaws was analyzed using the QuantiGene 2.0 Plex assay. Fold change in gene expression was compared to that in wild-type controls. a-h TNFɑ (a), IL-6 (b), interferon-γ (IFN-γ) (c), IL-4 (d), IL-23 (e), IL-17A (f), dickkopf-related protein 1 (Dkk1) (g), and sclerostin (SOST) (h). Data are expressed as the average fold change relative to the wild-type control group. Values are mean ± SEM; n = 12 mice per group except for the wild-type control (n = 2); *P < 0.05, **P < 0.01, ***P < 0.001, versus controls. Sham = sham-operated mice, OVx = ovariectomized mice, OVx + E2 = 17β-estradiol-treated ovariectomized mice