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Table 5 Unadjusted, age-adjusted, and multivariable-adjusted HR of incident myocardial infarction or incident stroke

From: Is gout a risk equivalent to diabetes for stroke and myocardial infarction? A retrospective claims database study

 

Incident MI HR (95% CI)

p value

Incident stroke HR (95% CI)

p value

Unadjusted

Age-adjusted

Multivariable-adjusteda

Unadjusted

Age-adjusted

Multivariable-adjusteda

Gout and diabetes

1.89 (1.75–2.05)

1.61 (1.49–1.75)

1.35 (1.25–1.47)

1.91 (1.74–2.10)

1.61 (1.46–1.77)

1.42 (1.29–1.56)

 

p < 0.0001

p < 0.0001

p < 0.0001

p < 0.0001

p < 0.0001

p < 0.0001

Gout, no diabetes

1.08 (1.01–1.15)

0.87 (0.81–0.92)

0.81 (0.76–0.87)

1.35 (1.26–1.45)

1.06 (0.99–1.14)

1.02 (0.95–1.10)

 

p = 0.0187

p < 0.0001

p < 0.0001

p < 0.0001

p = 0.1005

p = 0.5723

No diabetes, no gout

0.41 (0.39–0.42)

0.45 (0.43–0.46)

0.53 (0.51–0.55)

0.45 (0.43–0.47)

0.50 (0.48–0.52)

0.57 (0.54–0.60)

 

p < 0.0001

p < 0.0001

p < 0.0001

p < 0.0001

p < 0.0001

p < 0.0001

Diabetes, no gout

Reference

Reference

Reference

Reference

Reference

Reference

  1. MI Myocardial infarction
  2. A nonsignificant HR in age- and multivariable-adjusted models denotes that, with patients with diabetes as the reference category, the HR of incident stroke was similar; in other words, gout is a cerebrovascular risk factor equivalent to diabetes.
  3. Multivariable-adjusted analysis included patients without MI, stroke, and heart disease in the baseline period
  4. aAdjusted for age, sex, race, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, chronic kidney disease, and peripheral vascular disease. Additional adjustment for immune diseases led to minimal attenuation of OR but no change in p value or interpretation
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Arthritis Research & Therapy

ISSN: 1478-6362

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