|
Marker
|
Active AAV (n = 169)
|
Healthy control subjects (n = 30)
|
p Value
|
AUCa
|
COPb
|
Sensitivity
|
Specificity
|
LR + c
|
|---|
|
CRP, mg/dl
|
3.79 (0.9–8.24)
|
0.01 (0.005–0.03)
|
< 0.0001d
|
0.96
|
0.16
|
86
|
97
|
25.9
|
|
TIMP1, ng/ml
|
333 (226–426)
|
132 (115–148)
|
< 0.0001d
|
0.94
|
183
|
86
|
97
|
25.9
|
|
LRG1, μg/ml
|
86.1 (53.7–134)
|
16.3 (13.6–20.7)
|
< 0.0001d
|
0.97
|
28.8
|
93
|
100
|
–
|
|
TNC, ng/ml
|
145 (84.3–265)
|
48.0 (35.4–64.3)
|
< 0.0001d
|
0.88
|
93.1
|
72
|
93
|
10.8
|
|
S100A8/A9, μg/ml
|
5.8 (3.5–8.9)
|
1.3 (1.1–1.8)
|
< 0.0001d
|
0.96
|
2.2
|
91
|
93
|
13.6
|
|
CD93, ng/ml
|
226 (167–300)
|
125 (103–139)
|
0.0005d
|
0.89
|
149
|
82
|
93
|
12.3
|
|
TKT, ng/ml
|
124 (69.7–183)
|
33.1 (15.1–42.6)
|
< 0.0001d
|
0.94
|
58.1
|
83
|
93
|
12.5
|
|
MMP9, ng/ml
|
791 (429–1382)
|
517 (294–838)
|
0.0158d
|
0.67
|
642
|
62
|
70
|
2.05
|
-
Abbreviations: ANCA Antineutrophil cytoplasmic antibody, COP Cutoff point, CRP C-reactive protein, LR Likelihood ratio, LRG1 Leucine-rich alpha-2-glycoprotein 1, MMP9 Matrix metalloproteinase 9, MPO Myeloperoxidase, TIMP1 Tissue inhibitor of metalloproteinase 1, TKT Transketolase, TNC Tenascin C
- Values are median (IQR)
-
aAn AUC of 1 indicates perfect discrimination between groups; an AUC of 0.5 indicates no discrimination
-
bCOP is the maximum sum of sensitivity and specificity
-
cLR+ at the COP, which equals sensitivity/(1 − specificity)
-
d
p < 0.05 by analysis of covariance adjusted for age and sex
