Incretins in patients with rheumatoid arthritis

Table 5 Glucose, insulin, C peptide, GIP and GLP-1 concentrations after meal test in RA patients and controls

		Glucose	p	Insulin	p	C peptide	p	GIP	p	GLP-1	p
Maximum response	Controls	102 (96-141)	0.11	27.2 (11.2-44.8)	0.49	4.98 (2.99-6.03)	0.20	1.49 (1.22-2.08)	0.73	0.59 (0.24-0.61)	0.73
	RA patients	134 (127-138)	0.11	26.8 (12.8-56.0)	0.49	5.85 (3.98-7.96)	0.20	1.48 (1.37-1.81)	0.73	0.48 (0.45-0.62)	0.73
Minutes to max. response	Controls	30 (30-240)	0.39	30 (30-60)	0.36	30 (30-60)	0.029	150 (60-210)	0.08	60 (60-120)	0.34
	RA patients	75 (45-90)	0.39	45 (30-105)	0.36	75 (60-105)	0.029	45 (15-135)	0.08	45 (30-105)	0.34
AUC	Controls	691 ± 78	0.006	92 ± 52	0.87	21 ± 7	0.23	9 ± 2	0.69	3 ± 1	0.34
	RA patients	843 ± 114	0.006	105 ± 84	0.87	35 ± 21	0.23	10 ± 2	0.69	3 ± 1	0.34
Early response AUC	Controls	195 ± 39	0.34	39 ± 23	0.99	7 ± 2	0.87	2.2 ± 0.3	0.28	0.7 ± 0.4	0.78
	RA patients	217 ± 21	0.34	38 ± 29	0.99	7 ± 2	0.87	2.6 ± 0.6	0.28	0.8 ± 0.3	0.78
Late response AUC	Controls	411 ± 44	0.054	33 ± 24	0.37	11 ± 3	0.12	6.0 ± 1.0	0.61	1.7 ± 0.8	0.40
	RA patients	507 ± 99	0.054	59 ± 48	0.37	23 ± 17	0.12	6.2 ± 1.2	0.61	2.0 ± 0.6	0.40

Data expressed as median (interquartile range)
AUC are depicted as average ± standard deviation
Early response refers to the AUC from baseline to minute 60
Late response refers to the AUC from minute 60 to minute 240
Maximum response is expressed in the molecules units median and interquartile range
Minutes to maximum response is expressed in median and interquartile range
GLP-1: Glucagon-Like Peptide 1; GIP: gastric inhibitory polypeptide

ISSN: 1478-6362