| | |
Glucose
|
p
|
Insulin
|
p
|
C peptide
|
p
|
GIP
|
p
|
GLP-1
|
p
|
|---|
|
Maximum response
|
Controls
|
102 (96-141)
|
0.11
|
27.2 (11.2-44.8)
|
0.49
|
4.98 (2.99-6.03)
|
0.20
|
1.49 (1.22-2.08)
|
0.73
|
0.59 (0.24-0.61)
|
0.73
|
| |
RA patients
|
134 (127-138)
|
26.8 (12.8-56.0)
|
5.85 (3.98-7.96)
|
1.48 (1.37-1.81)
|
0.48 (0.45-0.62)
|
|
Minutes to max. response
|
Controls
|
30 (30-240)
|
0.39
|
30 (30-60)
|
0.36
|
30 (30-60)
|
0.029
|
150 (60-210)
|
0.08
|
60 (60-120)
|
0.34
|
| |
RA patients
|
75 (45-90)
|
45 (30-105)
|
75 (60-105)
|
45 (15-135)
|
45 (30-105)
|
|
AUC
|
Controls
|
691 ± 78
|
0.006
|
92 ± 52
|
0.87
|
21 ± 7
|
0.23
|
9 ± 2
|
0.69
|
3 ± 1
|
0.34
|
| |
RA patients
|
843 ± 114
|
105 ± 84
|
35 ± 21
|
10 ± 2
|
3 ± 1
|
|
Early response AUC
|
Controls
|
195 ± 39
|
0.34
|
39 ± 23
|
0.99
|
7 ± 2
|
0.87
|
2.2 ± 0.3
|
0.28
|
0.7 ± 0.4
|
0.78
|
| |
RA patients
|
217 ± 21
|
38 ± 29
|
7 ± 2
|
2.6 ± 0.6
|
0.8 ± 0.3
|
|
Late response AUC
|
Controls
|
411 ± 44
|
0.054
|
33 ± 24
|
0.37
|
11 ± 3
|
0.12
|
6.0 ± 1.0
|
0.61
|
1.7 ± 0.8
|
0.40
|
| |
RA patients
|
507 ± 99
|
59 ± 48
|
23 ± 17
|
6.2 ± 1.2
|
2.0 ± 0.6
|
- Data expressed as median (interquartile range)
- AUC are depicted as average ± standard deviation
- Early response refers to the AUC from baseline to minute 60
- Late response refers to the AUC from minute 60 to minute 240
- Maximum response is expressed in the molecules units median and interquartile range
- Minutes to maximum response is expressed in median and interquartile range
- GLP-1: Glucagon-Like Peptide 1; GIP: gastric inhibitory polypeptide
