Changes in clinical disease activity are weakly linked to changes in MRI inflammation on treat-to-target escalation of therapy in rheumatoid arthritis

Table 4 Correlations between ΔDAS28_CRP and ΔMRI scores

Change in MRI scores (over 4 months)	Number of observations	Spearman correlation coefficients	p value
Δtotal MRI(i)	66*	0.36	0.003
Δosteitis	68	0.12	0.33
Δsynovitis	66	0.21	0.09
Δtendonitis	66	0.33	0.007
Δerosion	67	–0.02	0.87

*Sixty-six scan pairs available, includes eight pairs from the four patients who transitioned from Group A to Group B
DAS28 _CRP disease activity score (28 joints) incorporating C-reactive protein, MRI magnetic resonance imaging, MRI(i) total MRI inflammation score at the wrist (sum of synovitis, osteitis and tendonitis scores)