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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus

Fig. 3

In vivo depletion of CD11c+ B cells attenuated the production of antichromatin IgG after cGVHD induction. a Design of transient depletion of CD11c+ B cells in the cGVHD study. Mice received three intraperitoneal (i.p.) injections of 100 ng diphtheria toxin (DT) (n = 5) or negative control (PBS; n = 5) every other day after 7 days from an intraperitoneal injection of splenocytes from Bm12; after 14 days, the recipient mice were sacrificed for analysis. b Flow cytometric analysis of CD19+CD11c+ cells in total spleen. c Antichromatin IgG and IgG2a autoantibodies were measured by ELISA in the serum of CD11c-DTR mice with cGVHD induction. Results are representative of three independent experiments. Values are shown as the mean ± SD. **P < 0.01, ***P < 0.001. IgG immunoglobulin G, OD optical density

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