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Table 1 Patients’ characteristics

From: Ultrasound verified inflammation and structural damage in patients with hereditary haemochromatosis-related arthropathy

  HH-WA (n = 24) HH-A (n = 26) HOA (n = 37)
Agea (years) 57.1 (13.0) 57.8 (9.7) 60.1 (9.5)
Female, n (%) 8 (33.3)* 5 (19.2)* 34 (91.9)
Disease duration since diagnosisb (years) 7.5 (3.2–22.8)* 10.3 (0.8–27.6)* 0.9 (0–23.5)
Organ involvement HH, n (%)
 Aminotransferase elevation 4 (16.7) 2 (7.7) -
 Liver fibrosis/cirrhosis 0 5 (19.2)¥
 Impaired glucose tolerance 1 (4.2) 2 (7.7)
 Diabetes mellitus 2 (8.3) 3 (11.5)
 Cardiomyopathy 0 0
Morning stiffnessb (minutes) 0 (0–10) 3 (0–180) 7.5 (0–120)
EGAcb (mm) 0 (0–29) 13.5 (0–61) 10 (1–53)
PGAcb (mm) 5 (0–65) 25 (0–74) 25 (0–77)
Pain handscb (mm) 0.5 (0–18) 31 (0–72) 24.5 (0–86)
Pain hipcb (mm) 1 (0–44) 10.5 (0–58) 6 (0–91)
Pain kneecb (mm) 0.5 (0–50) 25 (0–76) 10 (0–86)
Pain anklecb (mm) 1 (0–60) 35.5 (0–96)* 3 (0–86)
Hand functioncb (mm) 4.5 (0–66) 39.5 (0–100) 47 (0–92)
Bony swollen jointsb 0 (0–12) 2.5 (0–14)* 7 (0–24)
≥1 Bony swollen joint, n (%) 8 (33.3) 16 (61.5)** 36 (97.3)
Tender jointsb 0 (0–31) 4 (0–29) 3 (0–40)
≥1 Tender joint, n (%) 6 (25.0) 22 (84.6) 30 (81.1)
Swollen jointsb 0 (0–1) 0 (0–7) 0 (0–6)
≥1 Swollen joint, n (%) 2 (8.3) 6 (23.1) 8 (21.6)
ESRb (mm/1st hour) 9 (0–29) 8.5 (1–36) 6 (2–34)
CRPb (mg/L) 0.5 (0–4)* 0.5 (0–4.2)* 1.3 (0.1–12.6)
Ferritinb (at visit) (ng/ml) 83.6 (28–1060) 66.1 (14–853) 100.0 (19–266)
  1. Pain scores, global assessment, function, morning stiffness, bony swollen joints, tender joints and swollen joints were not compared between HH-WA and HH-A or HH-WA and HOA because by definition, there were differences between these groups
  2. HH hereditary haemochromatosis, CRP C-reactive protein (normal value 0–5 mg/L), EGA evaluator global assessment, ESR erythrocyte sedimentation rate (normal range 0–10 mm/1st hour), HH-A hereditary haemochromatosis with arthropathy, HH-WA hereditary haemochromatosis without arthropathy, HOA hand osteoarthritis, n number, PGA patient global assessment
  3. aMean (standard deviation)
  4. bMedian (range)
  5. cAll measured on a visual analogue scale with a range 0–100 mm, with 0 = best, 100 = worst
  6. *p < 0.01, **p < 0.001 compared to HOA; ¥ p ≤ 0.05 compared to HH-WA; p values are not adjusted for multiple testing