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Table 1 Patients’ characteristics

From: Ultrasound verified inflammation and structural damage in patients with hereditary haemochromatosis-related arthropathy

 

HH-WA (n = 24)

HH-A (n = 26)

HOA (n = 37)

Agea (years)

57.1 (13.0)

57.8 (9.7)

60.1 (9.5)

Female, n (%)

8 (33.3)*

5 (19.2)*

34 (91.9)

Disease duration since diagnosisb (years)

7.5 (3.2–22.8)*

10.3 (0.8–27.6)*

0.9 (0–23.5)

Organ involvement HH, n (%)

 Aminotransferase elevation

4 (16.7)

2 (7.7)

-

 Liver fibrosis/cirrhosis

0

5 (19.2)Â¥

 Impaired glucose tolerance

1 (4.2)

2 (7.7)

 Diabetes mellitus

2 (8.3)

3 (11.5)

 Cardiomyopathy

0

0

Morning stiffnessb (minutes)

0 (0–10)

3 (0–180)

7.5 (0–120)

EGAcb (mm)

0 (0–29)

13.5 (0–61)

10 (1–53)

PGAcb (mm)

5 (0–65)

25 (0–74)

25 (0–77)

Pain handscb (mm)

0.5 (0–18)

31 (0–72)

24.5 (0–86)

Pain hipcb (mm)

1 (0–44)

10.5 (0–58)

6 (0–91)

Pain kneecb (mm)

0.5 (0–50)

25 (0–76)

10 (0–86)

Pain anklecb (mm)

1 (0–60)

35.5 (0–96)*

3 (0–86)

Hand functioncb (mm)

4.5 (0–66)

39.5 (0–100)

47 (0–92)

Bony swollen jointsb

0 (0–12)

2.5 (0–14)*

7 (0–24)

≥1 Bony swollen joint, n (%)

8 (33.3)

16 (61.5)**

36 (97.3)

Tender jointsb

0 (0–31)

4 (0–29)

3 (0–40)

≥1 Tender joint, n (%)

6 (25.0)

22 (84.6)

30 (81.1)

Swollen jointsb

0 (0–1)

0 (0–7)

0 (0–6)

≥1 Swollen joint, n (%)

2 (8.3)

6 (23.1)

8 (21.6)

ESRb (mm/1st hour)

9 (0–29)

8.5 (1–36)

6 (2–34)

CRPb (mg/L)

0.5 (0–4)*

0.5 (0–4.2)*

1.3 (0.1–12.6)

Ferritinb (at visit) (ng/ml)

83.6 (28–1060)

66.1 (14–853)

100.0 (19–266)

  1. Pain scores, global assessment, function, morning stiffness, bony swollen joints, tender joints and swollen joints were not compared between HH-WA and HH-A or HH-WA and HOA because by definition, there were differences between these groups
  2. HH hereditary haemochromatosis, CRP C-reactive protein (normal value 0–5 mg/L), EGA evaluator global assessment, ESR erythrocyte sedimentation rate (normal range 0–10 mm/1st hour), HH-A hereditary haemochromatosis with arthropathy, HH-WA hereditary haemochromatosis without arthropathy, HOA hand osteoarthritis, n number, PGA patient global assessment
  3. aMean (standard deviation)
  4. bMedian (range)
  5. cAll measured on a visual analogue scale with a range 0–100 mm, with 0 = best, 100 = worst
  6. *p < 0.01, **p < 0.001 compared to HOA; ¥ p ≤ 0.05 compared to HH-WA; p values are not adjusted for multiple testing