Fig. 2
From: New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis
Model for DNA methylation of the MMP-13 promoter. CREB binds to the MMP-13 promoter when the −104 CpG is demethylated. HIF-2α binds to the MMP-13 promoter when the −110 CpG is demethylated. C/EBPβ and RunX2 bind between base pairs −103 and −97 and −138 and −132, respectively, and cooperate to promote MMP-13 mRNA transcription. At the same time, HIF-2α promotes C/EBPβ mRNA transcription by binding between base pairs −103 and −46 of the C/EBPβ promoter