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Table 3 Differential diagnosis of RA and other rheumatic diseases using cutoff points for serum CTGF and ACPA

From: Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

  AUC (95% CI) S.e. Cutoff Sensitivity % Specificity % P value
RA vs AS CTGF 0.94 (0.91, 0.97) 0.01 73.35 86.18 93.48 <0.0001
ACPA 0.88 (0.84, 0.92) 0.01 34.96 77.42 90.22 <0.0001
RA vs gout CTGF 0.95 (0.93, 0.98) 0.01 84.42 84.33 97.3 <0.0001
ACPA 0.89 (0.86, 0.93) 0.02 49.23 68.2 98.65 <0.0001
RA vs OA CTGF 0.94 (0.92, 0.97) 0.01 46.75 88.48 90.38 <0.0001
ACPA 0.89 (0.85, 0.93) 0.02 42.33 71.89 94.23 <0.0001
RA vs PSS CTGF 0.86 (0.82, 0.90) 0.02 151 75.12 90.77 <0.0001
ACPA 0.83 (0.78, 0.88) 0.03 43.46 71.43 90.77 <0.0001
RA vs SLE CTGF 0.92 (0.89, 0.95) 0.02 79.64 85.71 95.83 <0.0001
ACPA 0.84 (0.79, 0.88) 0.02 76.56 65.44 98.61 <0.0001
  1. P value compared with Null hypothesis: true area % 0.5
  2. Abbreviations: AUC area under the receiver operating characteristic curve, 95% CI 95% confidence interval, S.e. standard error, RA rheumatoid arthritis, AS ankylosing spondylitis, OA osteoarthritis, pSS primary Sjögren’s syndrome, SLE systemic lupus erythematosus, ACPA anti-citrullianted protein antibodies, CTGF connective tissue growth factor