Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

Table 3 Differential diagnosis of RA and other rheumatic diseases using cutoff points for serum CTGF and ACPA

		AUC (95% CI)	S.e.	Cutoff	Sensitivity %	Specificity %	P value
RA vs AS	CTGF	0.94 (0.91, 0.97)	0.01	73.35	86.18	93.48	<0.0001
RA vs AS	ACPA	0.88 (0.84, 0.92)	0.01	34.96	77.42	90.22	<0.0001
RA vs gout	CTGF	0.95 (0.93, 0.98)	0.01	84.42	84.33	97.3	<0.0001
RA vs gout	ACPA	0.89 (0.86, 0.93)	0.02	49.23	68.2	98.65	<0.0001
RA vs OA	CTGF	0.94 (0.92, 0.97)	0.01	46.75	88.48	90.38	<0.0001
RA vs OA	ACPA	0.89 (0.85, 0.93)	0.02	42.33	71.89	94.23	<0.0001
RA vs PSS	CTGF	0.86 (0.82, 0.90)	0.02	151	75.12	90.77	<0.0001
RA vs PSS	ACPA	0.83 (0.78, 0.88)	0.03	43.46	71.43	90.77	<0.0001
RA vs SLE	CTGF	0.92 (0.89, 0.95)	0.02	79.64	85.71	95.83	<0.0001
RA vs SLE	ACPA	0.84 (0.79, 0.88)	0.02	76.56	65.44	98.61	<0.0001

P value compared with Null hypothesis: true area % 0.5
Abbreviations: AUC area under the receiver operating characteristic curve, 95% CI 95% confidence interval, S.e. standard error, RA rheumatoid arthritis, AS ankylosing spondylitis, OA osteoarthritis, pSS primary Sjögren’s syndrome, SLE systemic lupus erythematosus, ACPA anti-citrullianted protein antibodies, CTGF connective tissue growth factor

ISSN: 1478-6362