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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Prediction of progression of damage to articular cartilage 2 years after anterior cruciate ligament reconstruction: use of aggrecan and type II collagen biomarkers in a retrospective observational study

Fig. 2

ROC curves for Δdi-C6S level, Δdi-C4S level, KS level, C6S/C4S, and the presence of high-grade cartilage progression. Black dots in the figure panels indicate cut-off points. a ROC analysis for the level of Δdi-C6S and the presence of high-grade cartilage progression (area under the ROC curve: 0.746 [95% CI 0.612–0.880]; 60.0% sensitivity and 83.0% specificity for a cut-off of 55.7 nmol/ml). b ROC analysis for the level of Δdi-C4S and the presence of high-grade cartilage progression (area under the ROC curve 0.618 [95% CI 0.478–0.758]; 93.3% sensitivity and 46.8% specificity for a cut-off of 19.0 nmol/ml). c ROC analysis for the level of KS and the presence of high-grade cartilage progression (area under the ROC curve: 0.699 [95% CI 0.526–0.872]; 73.3% sensitivity and 70.2% specificity for a cut-off of 10.6 μg/ml). d ROC analysis for C6S/C4S (ratio of Δdi-C6S to Δdi-C4S) and the presence of high-grade cartilage progression (area under the ROC curve: 0.689 [95% CI 0.546–0.833]; 93.3% sensitivity and 40.0% specificity for a cut-off of 4.6)

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